Biotechnology Letters

, Volume 16, Issue 6, pp 617–620 | Cite as

Acetic acid production by Acetobacter aceti in a silicone tube bioreactor

  • Kiyoshi Toda
  • Tomoko Asakura


Continuous acetic acid fermentation was carried out using a column reactor, in which 20 to 200 thin silicone tubes (0.33 mm in outer diameter) were packed to supply oxygen by permeation. The highest value of volumetric oxygen transfer coefficient determined by the sulfite oxidation method was 2,860 h−1, which was comparable to that of a well agitated and aerated fermentor. The maximum production rate of acetic acid by the bacterial films of Acetobacter aceti M7 grown on the shell-side surface of the tubes was 38.0 g/lh at an acetic acid concentration of 44.5 g/l. This was 29 times that of a continuous culture using a jar fermentor.


Fermentation Sulfite Oxygen Transfer Silicone Tube Acid Fermentation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Cooper, C.M.;Fernstrom,G.A.;Miller,S.A.(1944) Ind.Eng.Chem. 36, 504–509Google Scholar
  2. Matsuoka,H.; Fukada,S.; Toda,K. (1992) Biotechnol. Bioeng., 40, 346–352Google Scholar
  3. Park Y.S.;Ohtake,H.; Toda,K.(1989) Biotechnol. Bioeng., 33, 918–923Google Scholar
  4. Park,Y.S.; Toda,K.(1992) Biotechnol. Letters, 14, 609–612Google Scholar
  5. Sinclair,C.G.;Ryder, D.L.(1975)Biotechnol. Bioeng., 17, 375–398Google Scholar
  6. Toda,K.;Park, Y.S.;Asakura, T.; Cheng, C.Y.; Ohtake, H.(1989) Appl.Microbiol. Blotechnol., 30, 559–563Google Scholar

Copyright information

© Chapman & Hall 1994

Authors and Affiliations

  • Kiyoshi Toda
    • 1
  • Tomoko Asakura
    • 1
  1. 1.Institute of Molecular and Cellular Biosciences, The University of TokyoTokyoJapan

Personalised recommendations