A new bioadhesive for in vivo bone adhesion

A new bone adhesive was used to facilitate the union of bone fragments detached and repositioned on the tibia of dogs. The sites were X-rayed and histologically examined 1 and 6 weeks post-operatively. By 6 weeks, the bone fragments were found to be solidly attached in their original sites. Histological examination revealed no signs of inflammation, infection or any other adverse reactions, neither on the operated bone, nor in remote tissues of internal organs (spleen, lung, liver, kidney, and lymph nodes). The tested specimens exhibit, de novo bone growth into the adhesive, concomitant with clear signs of biodegradation of the adhesive. Additional in vivo experiments were carried out in white rats, whereby the adhesive was implanted subcutaneously and it became evident that the implanted material enabled new bone formation (ectopic), with no adverse effects within the immediate site as well as in the remote areas. Moreover, the biocompatible nature of the material revealed distinct signs of biodegradability.