Evaluation of tricalciumphosphate/ hydroxyapatite cement for tooth replacement: an experimental animal study

  • J. A. Jansen
  • J. E. De Ruijter
  • H. G. Schaeken
  • J. P. C. M. Van Der Waerden
  • J. A. Planell
  • F. C. M. Driessens


A calciumphosphate cement, consisting mainly of tricalciumphosphate (85% α-TCP and 15% β-TCP), was inserted in 16 surgical defects created in the tibia of goats. X-ray diffraction (XRD) and energy dispersive spectroscopy (EDS) showed that after 3 months of implantation the α-TCP was transformed to hydroxyapatite (HA). Histological evaluation revealed that the presence of cement stimulated the ingrowth of bone compared with unfilled cavities. Active resorption and remodelling of cement particles was observed. The cement did not evoke an inflammatory reaction. At 6 months after implantation no further changes in the composition of the cement occurred. All remaining material was surrounded by mature bone.


Polymer Experimental Animal Animal Study Hydroxyapatite Inflammatory Reaction 
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Copyright information

© Chapman & Hall 1995

Authors and Affiliations

  • J. A. Jansen
    • 1
  • J. E. De Ruijter
    • 1
  • H. G. Schaeken
    • 1
  • J. P. C. M. Van Der Waerden
    • 1
  • J. A. Planell
    • 2
  • F. C. M. Driessens
    • 2
  1. 1.Department of Oral Function, Laboratory of Biomaterials, Dental SchoolUniversity of NijmegenNijmegenThe Netherlands
  2. 2.Department de Ciència dels Materials i Enginyeria Metal-lúrgicaUniversitat Politècnica de CatalunyaBarcelonaSpain

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