The rheological behaviour of animal vitreus and its comparison with vitreal substitutes

  • M. Mensitieri
  • L. Ambrosio
  • L. Nicolais
  • L. Balzano
  • D. Lepore
Papers

Some important eye pathologies, such as diabetic proliferative retinopathy and retinal detachment, are strictly connected to different gel vitreus alterations. Therefore there is a strong need in ophthalmology for vitreal substitutes. Until now many synthetic and natural polymers have been tested as vitreal substitutes, but no one has proved to be an ideal vitreal substitute. An ideal vitreal substitute, apart from other characteristics, such as transparency, permanency, biocompatibility, etc. must have a rheological behaviour compatible with the surrounding tissues. The viscoelastic behaviour of different animals' gel vitreus, evaluated by means of steady shear viscosity and small-amplitude oscillatory measurements, is typical of solid-like rubbery gels with dynamic elastic modulus G′ higher than the dynamic viscous modulus G″ in the typical frequency range investigated (0.05–10 Hz). On the other hand the rheological behaviour of current or candidate vitreal substitutes (silicone oil, HPMC, high molecular weight hyaluronic acid and chemically-crosslinked hyaluronic acid), analysed with the same technique, is generally different from that of natural vitreus.

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References

  1. 1.
    J. E. SCOTT, Eye 6 (1992) 553.Google Scholar
  2. 2.
    E. A. BALAZS and J. L. DENLINGER, in “The eye, Vol. Ia, Vegetative physiology and biochemistry”, edited by H. DAVSON, 3rd edition (Academic Press, New York, 1984) p. 533.Google Scholar
  3. 3.
    F. A. BETTELHEIM and T. J. Y. WANG, Exp. Eye Res. 23 (1976) 435.Google Scholar
  4. 4.
    C. L. SCHEPENS, Bull. Soc. Belge Opthal. 223-I (1987) 85.Google Scholar
  5. 5.
    M. DOI, in “Materials science and technology, Vol. 12, Structure and properties of polymers”, edited by E. L. THOMAS (VCH, Weinheim, 1993) p. 389.Google Scholar
  6. 6.
    J. D. FERRY, in “Viscoelastic properties of polymers” (J. Wiley, New York, 1970).Google Scholar
  7. 7.
    J. E. SCOTT, Biochem. J. 252 (1988) 313.Google Scholar
  8. 8.
    R. MAYNE, R. G. BREWTON, D. W. WRIGHT and Z. X. REN, in “Biochemistry of the eye”, Biochemical Society Transactions 19 (1991).Google Scholar
  9. 9.
    J. L. DENLINGER and E. A. BALAZS, in “Vision and visual health care, Vol. 2-Viscoelastic materials”, edited by E. S. ROSEN (Pergamon Press, Oxford, 1989) p. 185.Google Scholar
  10. 10.
    U. B. G. LAURENT and K. A. GRANATH, Exp. Eye Res. 36 (1983) 481.Google Scholar
  11. 11.
    S. B. ROSS-MURPHY, in “Polymer gels. Fundamentals and biomedical applications”, edited by D. De ROSSI, K. KAJIWARA, Y. OSADA and A. YAMAUCHI (Plenum Press, New York, 1991) p. 21.Google Scholar
  12. 12.
    V. P. GABEL, A. KAMPIK and J. BURKHARDT, Graefe's Arch. Clin. Exp. Ophthalmol. 225 (1987) 160.Google Scholar
  13. 13.
    E. S. ROSEN and R. P. F. GREGORY, in “Vision and visual health care, Vol. 2-Viscoelastic materials”, edited by E. S. ROSEN (Pergamon Press, Oxford, 1989) p. 31.Google Scholar
  14. 14.
    R. KOSTER and J. S. STILMA, Documenta Ophthalmologica 61 (1986) 247.Google Scholar
  15. 15.
    H. BOTHNER and O. WIK, in “Vision and visual health care, Vol. 2-Viscoelastic materials”, edited by E. S. ROSEN (Pergamon Press, Oxford, 1989) p. 53.Google Scholar
  16. 16.
    E. A. BALAZS, in “Vision and visual health care, Vol. 2-Viscoelastic materials”, edited by E. S. ROSEN (Pergamon Press, Oxford, 1989) p. 167.Google Scholar
  17. 17.
    J. L. DENLINGER and E. A. BALAZS, Exp. Eye Res. 30 (1980) 101.Google Scholar
  18. 18.
    United States Patent N. 4713488 (1987).Google Scholar
  19. 19.
    E. A. BALAZS, P. A. BLAND, J. L. DENLINGER, A. I. GOLDMAN, N. E. LARSEN, E. A. LESHCHINER, A. LESHCHINER and B. MORALES, Blood Coagulation and Fibrinolysis 2 (1991) 173.Google Scholar
  20. 20.
    A. VADAZS, E. A. BALAZS, A. GOLDMAN et al., Proc. Int. Soc. for Eye Res. 5 (1988) 67.Google Scholar

Copyright information

© Chapman & Hall 1994

Authors and Affiliations

  • M. Mensitieri
    • 1
  • L. Ambrosio
    • 1
  • L. Nicolais
    • 1
  • L. Balzano
    • 2
  • D. Lepore
    • 2
  1. 1.Institute of Composite Materials Technology-CNRNaplesItaly
  2. 2.Department of OphthalmologyUniversità Cattolica del Sacro CuoreRomeItaly

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