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Cell Biology and Toxicology

, Volume 4, Issue 4, pp 487–493 | Cite as

Synaptonemal complex damage as a measure of genotoxicity at meiosis

  • James W. Allen
  • Patricia A. Poorman
  • Lorraine C. Backer
  • James B. Gibson
  • Barbara Westbrook-Collins
  • Montrose J. Moses
Article

Synaptonemal complex aberrations can provide a sensitive measure of chemical-specific alterations to meiotic chromosomes. Mitomycin C, cyclophosphamide, amsacrine, ellipticine, colchicine, vinblastine sulfate, and cis platin exposures in mice have been shown to cause various patterns of synaptonemal complex structural damage and synaptic irregularity. These effects are suggestive of abnormal homologue pairinglsynapsis/recombination effects which, theoretically, could be implicated in mechanisms leading to aneuploidy and other potentially heritable chromosomal disorders.

Key words

genotoxicity meiosis synaptonemal complex 

Abbreviations

C

colchicine

cis-DDP

cisplatin

CP

cyclophosphamide

EL

ellipticine

i.p.

intraperitoneal

i.t.

intratesticular

m-AMSA

amsacrine

MC

mitomycin C

SC

synaptonemal complex

VS

vinblastine sulfate

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References

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Copyright information

© Princeton Scientific Publishing Co., Inc 1988

Authors and Affiliations

  • James W. Allen
    • 1
  • Patricia A. Poorman
    • 2
  • Lorraine C. Backer
    • 3
  • James B. Gibson
    • 4
  • Barbara Westbrook-Collins
    • 1
  • Montrose J. Moses
    • 4
  1. 1.Genetic Toxicology DivisionHealth Effects Research Laboratory U.S. Environmental Protection AgencyResearch Triangle Park
  2. 2.Genetic Toxicology LaboratoryBurroughs Wellcome Co.Research Triangle Park
  3. 3.Environmental Health Research and TestingResearch Triangle Park
  4. 4.Department of AnatomyDuke University Medical CenterDurham

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