Clinical & Experimental Metastasis

, Volume 10, Issue 5, pp 337–344 | Cite as

DNA ploidy of primary hepatocellular carcinoma and pulmonary metastases

  • Yasuhiro Yoshida
  • Takashi Kanematsu
  • Daisuke Korenaga
  • Takashi Sonoda
  • Keizo Sugimachi
Article
Received:
Accepted:

To better comprehend the differences in deoxyribonucleic acid (DNA) content between a primary hepatocellular carcinoma (HCC) and pulmonary metastatic nodules, tissue specimens taken at autopsy of 25 patients who had not received any drugs to treat the malignancy were examined using microspectrophotometry. The DNA distribution patterns were classified into Types I–III, and low (Types I and II) or high (Type III) ploidies, according to DNA distribution. Changes in the DNA content from high to low ploidies, namely DNA ploidy reduction from the primary lesion to pulmonary metastatic lesions, was evident in 9 of the 25 patients (36%), and changes from low to high were noted in 2 of the 25 patients (8%). The remaining 14 (56%) showed no evidence of changes in the DNA ploidy pattern. Reduction of DNA ploidy seen in HCC and its metastatic lesions in the lung may be one of the aspects of clonal evolution or selection mechanisms during the progression of tumor growth and metastasis.

Keywords

DNA content hepatocellular carcinoma pulmonary metastasis 
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Copyright information

© Rapid Communications of Oxford Ltd 1992

Authors and Affiliations

  • Yasuhiro Yoshida
    • 1
  • Takashi Kanematsu
    • 1
  • Daisuke Korenaga
    • 1
  • Takashi Sonoda
    • 1
  • Keizo Sugimachi
    • 1
  1. 1.Second Department of Surgery, Faculty of MedicineKyushu UniversityHigashi-ku, FukuokaJapan

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