Abstract
Breeding data from Eire and Great Britain confirm the hypothesis of Sponenberg (1985) that the harlequin colour of the Great Dane breed of dog is due the combined action of a dominant gene H with the merle gene M in the genotype H+M +. The typical bluish coloration induced by M is modified to white by the action of H. The H gene is a prenatal lethal when homozygous HH and this study offers clear indication that the heterozygous H + interacts with M to reduce the viability of white merle homozygotes H+MM.
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References
Anker, J., 1925. Die Vererbung der Haarfarbe beim Dachshunde. Dansk Viden. Selskab. biol. Medd. B. 4: 1–72.
Little, C. C., 1957. The inheritance of coat colour in dogs. Cornell University Press.
Little, C. C. & Jones, E. E., 1919. The inheritance of coat colour in great danes. J. Hered. 10: 309–320.
Mitchell, L. M., 1935. Dominant dilution and other colour factors in collie dogs. J. Hered. 26: 424–430.
Robinson, R., 1982. Genetics for dog breeders. Pergamon Press.
Schaible, R. H. & Brumbaugh, J. A., 1976. Electron microscopy of pigment cells in variegated and non-variegated, piebald spotted dogs. Pigment Cell 3: 191–200.
Sorby, A. & Davey, J. B., 1954. Ocular associations of merling in the coat colour of dogs. J. Genet. 52: 425–440.
Sponenberg, D. P., 1985. Inheritance of the harlequin colour in great danes. J. Hered. 76: 224–225.
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O'Sullivan, N., Robinson, R. Harlequin colour in the Great Dane dog. Genetica 78, 215–218 (1988). https://doi.org/10.1007/BF00055640
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DOI: https://doi.org/10.1007/BF00055640