, Volume 97, Issue 2, pp 205–210

Abnormal development of the locomotor activity in yellow larvae of Drosophila: a cuticular defect?

  • Nibaldo C. Inestrosa
  • Claudio E. Sunkel
  • Jorge Arriagada
  • Jorge Garrido
  • Raul Godoy-Herrera


The yellow (y) mutation of Drosophila melanogaster affects the development of behavior and morphology. We have analyzed some behavioral and morphological parameters during the development of y mutants. Wild-type third instar larvae move in straighter paths than larvae of the same age homozygous for the y mutation. At 96 h of age, the tracks of y larvae have 10 times as many loops as tracks of wild-type larvae, and at 120 h of age, y larvae show bending behavior about 2.5 times more frequently than do wild-type. Consequently, they do not disperse as much as wild-type larvae. Concomitant with the behavioral changes, the larvae present a defect in the morphology of large chaetae in the larval denticle belts, particularly of 2nd and 3rd instars, both with light and scanning electron microscopes. These results suggest that a cuticular defect is probably involved in the abnormal locomotor activity observed in y larvae of Drosophila melanogaster.

Key words

Drosophila melanogaster cuticular structures larvae yellow gene locomotor behavior 


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  1. Bastock, M., 1956, A gene mutation that changes a behavior pattern. Evolution 10: 421–439.Google Scholar
  2. Beissmann, H., 1985. Molecular analysis of the Yellow gene (y) region of Drosophila melanogaster. Proc. Natl. Acad. Sci. U.S.A. 82: 7369–7373.Google Scholar
  3. Brehme, K.S., 1941. The effect of adult body color mutations upon the larva of Drosophila melanogaster. Proc. Natl. Acad. Sci. U.S.A. 27: 254–261.Google Scholar
  4. Burdick, A.B., 1954. New medium of reproductive quality stable at room temperature. Drosophila Infor. Serv. 28: 170.Google Scholar
  5. Burnet, B. & K. Connolly, 1974, Activity and sexual behavior in Drosophila melanogaster, pp. 201–258 in The Genetics of Behavior, edited by J.H.F.Van Abeelen, Elsevier, Amsterdam.Google Scholar
  6. Burnet, B., K. Connolly & B. Harrison, 1973. Phenocopies of pigmentary and behavioral effects of Yellow mutant in Drosophila induced by α-dimethyltyrosine. Science 181: 1059–1060.Google Scholar
  7. Burnet, B. & R. Wilson, 1980. Pattern mosaicism for behavior controlled by the Yellow locus in Drosophila melanogaster. Genet. Res. 36: 235–247.Google Scholar
  8. Cambiazo, V. & N.C. Inestrosa, 1990. Proteoglycan production in Drosophila egg development: Effect of β-D-xyloside on proteoglycan synthesis and larval motility. Comp. Biochem. & Physiol. 97B: 307–314.Google Scholar
  9. Campusano, L., L. Carramolino, C.V. Cabrera, M. Ruiz-Gomez, R. Villares, A. Boronat & J. Modolell, 1985. Molecular genetics of the achaete-scute gene complex of Drosophila melanogaster. Cell 40: 327–338.Google Scholar
  10. Chia, W., G. Howes, M. Martin, Y.B. Meng, M. Mosses & S. Tsuboto, 1986a. Molecular analysis of the Yellow locus of Drosophila. EMBO J 5: 3597–3605.Google Scholar
  11. Chia, W., G. Howes, M. Martin & J.B. Meng, 1986b. Molecular analysis of Yellow. Drosophila Meeting, England (Abstr.)Google Scholar
  12. Garcia-Bellido, A., 1979. Genetic analysis of the achaete-scute system of Drosophila melanogaster. Genetics 91: 491–505.Google Scholar
  13. Garcia-Bellido, A. & P. Santamaria, 1978. Developmental analysis of the achete-scute system of Drosophila melanogaster. Geneties 88: 469–486.Google Scholar
  14. Godoy-Herrera, R., B. Burnet, K. Connolly & J. Gogharty, 1984. The development of locomotor activity in Drosophila melanogaster larvae. Heredity 52: 63–75.Google Scholar
  15. Green, Ch., B. Burnet & K.J. Connolly, 1983. Organizations and patterns of inter- and intraspecifie variation in the behavior of Drosophila larvae. Anim. Behav. 30: 282–291.Google Scholar
  16. Inestrosa, N.C., C. Sunkel & J.R. Arriagada, 1987. The sensory projection of Drosophila mutants which show abnormal wing formation or flying behavior. Brain Res. 416: 248–256.Google Scholar
  17. Inestrosa, N.C., H.B. Nader, J. Garride, L.O. Sampaio, E. Brandan & C.P. Dietrich, 1987. Glycosaminoglycan composition of cholinergic extracellular matrix: Chemical characteristies of the heparan sulfate chains. J. Neurosci. Res. 17: 256–264.Google Scholar
  18. Lindsley, D.L. & E.H. Grell, 1968. Genetic variations of Drosophila melanogaster. Carnegie Institute of Washington Publication No 627.Google Scholar
  19. Lohs-Schardin, M., C. Cremer & C. Nusslein-Volhard, 1979. A fate map of the larval epidermis of Drosophila melanogaster: localized defects following irradiation of the blastoderm with an ultraviolet laser microbeam. Dev. Biol. 73: 239–255.Google Scholar
  20. Nash, W.G., 1976. Patterns of pigmentation and color states regulated by the y locus in Drosophila melanogaster. Dev. Biol. 48: 336–343.Google Scholar
  21. Nash, W.G. & R.J. Yarkin, 1974. Genetic regulation and pattern formation: A study of Yellow locus in Drosophila melanogaster. Genet. Res. 24: 19–26.Google Scholar
  22. Pereira, H.S. & M. B. Sokolowski, 1993. Mutations in the larval foraging gene affect adult locomotory behavior after feeding in Drosophila melanogaster. Proc. Natl. Acad. Sci. U.S.A. 90: 5044–5046.Google Scholar
  23. van der Meer, J.M., 1977. Optically clean and permanent whole mount preparations for phase-contrast microscopy of cuticular structures of insect larvae. Drosophila Infor. Serv. 52: 160.Google Scholar
  24. Wilson, R., B. Burnet, L. Eastwood & K. Connolly, 1976. Behavioral pleiotropy of the yellow gene in Drosophila melanogaster. Genet. Res. 28: 75–88.Google Scholar

Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • Nibaldo C. Inestrosa
    • 1
  • Claudio E. Sunkel
    • 2
  • Jorge Arriagada
    • 1
  • Jorge Garrido
    • 1
  • Raul Godoy-Herrera
    • 3
  1. 1.Departamento de Biología Celular y Molecular, Facultad de Ciencias BiológicasPontificia Universidad Católica de ChileSantiagoChine
  2. 2.Molecular Gnetics LaboratoryUniversity of OportoPortoPortugal
  3. 3.Departamento de Biología Celular y Genética, Facultad de MedicinaUniversidad de ChileSantiagoChile
  4. 4.Molecular Neurobiology UnitP. Catholic University of ChileSantiagoChile

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