Cancer Causes & Control

, Volume 6, Issue 6, pp 532–538 | Cite as

Green-tea consumption and risk of stomach cancer: a population-based case-control study in Shanghai, China

  • Guo-pei Yu
  • Chung-cheng Hsieh
  • Li-yi Wang
  • Shun-zhang Yu
  • Xue-liang Li
  • Tie-hua Jin
Research Papers

The effect of drinking Chinese green tea on the risk of stomach cancer was evaluated in a population-based case-control study conducted in Shanghai, China, from October 1991 to December 1993. Eligible cases were incident cases of primary stomach cancer diagnosed during the study period among residents of Hongkou district and Nanhui county aged under 80 years. Controls were selected from the same street or commune where the case resided and were matched to the cases on age (within three years) and gender. A total of 711 cases and 711 matched controls, more than 90 percent of the eligible subjects, completed the interview. Information was obtained on the types of tea used, age when habitual tea drinking started, frequency of new batches of tea leaves used per day, number of cups brewed from each batch, total duration of drinking for each batch, strength and temperature of the tea consumed. Statistical analysis was based on modelling through conditional logistic regression. After adjusting for age, gender, place of residence, education, birthplace, alcohol consumption, and cigarette smoking, the odds ratio (OR) comparing drinkers of green tea with nondrinkers was 0.71 (95 percent confidence interval = 0.54–0.93). The adjusted OR decreased with increasing number of new batches of the green tea consumed each day (P value trend = 0.006). With the largest series of stomach cancer cases to date, this study found green-tea consumption associated with lower risk of stomach cancer. Among drinkers of green tea, the risk of stomach cancer did not depend on the age when habitual green-tea drinking started. Green tea may disrupt gastric carcinogenesis at both the intermediate and the late stages.

Key words

China stomach cancer tea 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Gao YT, McLaughlin JK, Blot BJ, Ji BT, Dai Q, Fraumeni JFJr. Reduced risk of esophageal cancer associated with green tea consumption. JNCI 1994; 86: 855–8.Google Scholar
  2. 2.
    Yang CS, Wang ZY. Tea and cancer. JNCI 1993; 85: 1038–49.Google Scholar
  3. 3.
    Higginson J. Etiological factors in gastrointestinal cancer in man. JNCI 1966; 37: 527–45.Google Scholar
  4. 4.
    Graham S, Lilienfeld AM, Tidings JE. Dietary and purgation factors in the epidemiology of gastric cancer. Cancer 1967; 20: 2224–34.Google Scholar
  5. 5.
    Trichopoulos D, Ouranos G, Day NE, et al. Diet and cancer of the stomach: a case-control study in Greece. Int J Cancer 1985; 36: 291–7.Google Scholar
  6. 6.
    Tajima K, Tominaga S. Dietary habits and gastrointestinal cancers: A comparative case-control study of stomach and large intestinal cancers in Nagoya, Japan. Jpn J Cancer Res 1985; 76: 705–16.Google Scholar
  7. 7.
    Risch HA, Jain M, Choi NW, et al. Dietary factors and the incidence of cancer of the stomach. Am J Epidemiol 1985; 122: 947–59.Google Scholar
  8. 8.
    Heilbrun LK, Nomura A, Stemmermann GN. Black tea consumption and cancer risk: a prospective study. Br J Cancer 1986; 54: 677–83.Google Scholar
  9. 9.
    Demirer T, Icli F, Uzunalimoglu O, Kucuk O. Diet and stomach cancer incidence: a case-control study in Turkey. Cancer 1990; 65: 2344–8.Google Scholar
  10. 10.
    La Vecchia C, Negri E, Franceschi S, D'Avanzo B, Boyle P. Tea consumption and cancer risk. Nutr Cancer 1992; 17: 27–31.Google Scholar
  11. 11.
    Agudo A, Gonzalez CA, Marcos G, et al. Consumption of alcohol, coffee, and tobacco, and gastric cancer in Spain. Cancer Causes Control 1992; 3: 137–43.Google Scholar
  12. 12.
    Kinlen LJ, Willows AN, Goldblatt P, Yudkin J. Tea consumption and cancer. Br J Cancer 1988; 58: 397–401.Google Scholar
  13. 13.
    Hansson LE, Nyrén O, Bergström R, et al. Diet and risk of gastric cancer. A population-based case-control study in Sweden. Int J Cancer 1993; 55: 181–9.Google Scholar
  14. 14.
    Kono S, Ikeda M, Tokudome S, Kuratsone M. A case-control study of gastric cancer and diet in northern Kyushu, Japan. Jpn J Cancer Res 1988; 79: 1064–74.Google Scholar
  15. 15.
    Yu GP, Hsieh C-c. Risk factors for stomach cancer: a population-based case-control study in Shanghai. Cancer Causes Control 1991; 2: 169–74.Google Scholar
  16. 16.
    Oguni I, Cheng SJ, Lin PZ, Hara Y. Protection against cancer risk by Japanese green tea. Prev Med 1992; 21: 332.Google Scholar
  17. 17.
    Breslow NE, Day NE. Statistical Methods in Cancer Research, Vol 1. The Analysis of Case-control Studies, Lyon, France: International Agency for Research on Cancer, 1980; IARC Sci. Pub. No. 32. 248–79.Google Scholar
  18. 18.
    Parkin DM, Muir C, Whelan SL, Gao YT, Ferlay J, Powell J. Cancer Incidence in Five Continents, Vol. 6. Lyon, France: International Agency for Research on Cancer, 1992; IARC Sci. Pub. No. 120.Google Scholar
  19. 19.
    Correa P. Human gastric carcinogenesis: a multistep and multifactorial process — First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. Cancer Res 1992; 52: 6735–40.Google Scholar
  20. 20.
    International Agency for Research on Cancer. Coffee, Tea, Mate, Methylxanthines, and Methylgloxyal. Lyon, France: International Agency for Research on Cancer, 1991; IARC Monogr Eval Carcinog Risk Hum, 51: 207–71.Google Scholar
  21. 21.
    La Vecchia C, Negri E, D'Avanzo B, Franceschi S. Food temperature and gastric cancer. Int J Cancer 1990; 46: 432–4.Google Scholar
  22. 22.
    Hu J, Nyrén O, Wolk A, et al. Risk factors for oesophageal cancer in northeast China. Int J Cancer 1994; 57: 38–46.Google Scholar
  23. 23.
    Wang HH, Antonioli DA, Goldman H. Comparative features of esophageal and gastric adenocarcinomas: recent changes in type and frequency. Hum Pathol 1986; 17: 482–7.Google Scholar
  24. 24.
    International Agency for Research on Cancer. Schistosomes, Liver Flukes and Helicobacter pylori. Lyon, France: International Agency for Research on Cancer, 1994; IARC Monogr Eval Carcinog Risk Hum, 61: 177–240.Google Scholar

Copyright information

© Rapid Science Publishers 1995

Authors and Affiliations

  • Guo-pei Yu
    • 1
    • 2
  • Chung-cheng Hsieh
    • 2
  • Li-yi Wang
    • 3
  • Shun-zhang Yu
    • 1
  • Xue-liang Li
    • 1
  • Tie-hua Jin
    • 4
  1. 1.Department of EpidemiologySchool of Public Health, Shanghai Medical UniversityShanghaiP.R. China
  2. 2.Department of EpidemiologyHarvard School of Public HealthBostonUSA
  3. 3.Hongkou Anti-epidemic StationShanghaiP.R. China
  4. 4.Nanhui Anti-epidemic StationShanghaiP.R. China
  5. 5.Cancer CenterUniversity of Massachusetts Medical CenterWorcesterUSA

Personalised recommendations