Development of an octocalcium phosphate cement

  • O. Bermúdez
  • M. G. Boltong
  • F. C. M. Driessens
  • J. A. Planell

From previous studies it is known that alpha-tertiary calcium phosphate and dicalcium phosphate form a cement upon mixing with water. In this study this cement was optimized in terms of the milling of the constituents, their molar ratio, the amount of hydroxyapatite added and the water/powder ratio. The optimum Ca/P molar ratio of the cement mixture was 1.36±0.03. X-ray diffraction showed the reaction product to be octocalcium phosphate. Addition of precipitated hydroxypatite of over 3% diminished the final strength of the cement significantly. However, admixtures of only 2% of precipitated hydroxyapatite (a) kept the final compressive strength at 30±5 MPa after soaking in Ringers solution at 37°C, (b) diminished the initial setting time from 27.5 to 10 min and the final setting time from 65 to 40 min, (c) diminished the time in which the final strength was reached from 36 to less than 14 h. The tensile strength of this cement is 19±1% of its compressive strength. The optimum water/powder ratio as found in this study was 0.30 g/g.


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  1. 1.
    S. E.Gruninger, C.Siew, L. C.Chow, A.O'Young, N. K.Ts'ao and W. E.Brown, J. Dent. Res. 63 (1984) 200Google Scholar
  2. 2.
    W. E. Brown and L. C. Chow, US Patent 4 518 430, May 21 (1985).Google Scholar
  3. 3.
    Y.Fukase, E. D.Eanes, S.Takagi, L. C.Chow and W. E.Brown, J. Dent. Res. 69 (1990) 1852.Google Scholar
  4. 4.
    P. W.Brown and M.Fulmer, J. Am. Ceram. Soc. 74 (1991) 934.Google Scholar
  5. 5.
    P. W.Brown, N.Hocker and S.Hoyle, J. Am. Ceram. Soc. 74 (1991) 1848.Google Scholar
  6. 6.
    B. R. Constantz, B. Barr and K. McVicker, US Patent 5 053 212, 1 October (1991).Google Scholar
  7. 7.
    J. Lemaitre, A. Mirtchi and A. Mortier, Silicates Industriels (1987) 141.Google Scholar
  8. 8.
    A. A.Mirtchi, J.Lemaitre and N.Terao, Biomaterials 10 (1989) 475.Google Scholar
  9. 9.
    A. A.Mirtchi, J.Lemaitre and E.Munting, Biomaterials. 10 (1989) 634.Google Scholar
  10. 10.
    F. C. M.Driessens, M. G.Boltong, O.Bermudez and J. A.Planell, J. Mater. Sci. Mat. Med. 4 (1993) 503.Google Scholar
  11. 11.
    B. R. Constantz, B. M. Barr, J. Quiaoit, I. C. Ison, J. T. Baker, L. McKinney, S. B. Goodman, D. R. Summer and S. Gunasekaran, Fourth World Biomaterials Congress, Berlin, 1992, Abstract 56.Google Scholar
  12. 12.
    H.Monma, A.Makishima, M.Mitomo and T.Ikegami, Nippon Seramikkusu Kyokai Gakujutsu Ronbunshi 96 (1988) 878.Google Scholar
  13. 13.
    F. C. M.Driessens and R. M. H.Verbeeck, “Biominerals” (CRC Press, Boca Raton, 1990).Google Scholar
  14. 14.
    F. C. M.Driessens and R. M. H.Verbeeck, Z. Naturforsch. 41C (1986) 468.Google Scholar
  15. 15.
    F. C. M.Driessens, G.Schaafsma, E. C. M.VanBerestijn and J.Rotgans, Z. Orthop. 124 (1986) 599.Google Scholar
  16. 16.
    N.Nishimura, T.Yamamuro, Y.Taguchi, M.Yakenaga, T.Nakamura, T.Kokubo and S.Yoshihara, J. Appl. Biomaterials 2 (1991) 219.Google Scholar

Copyright information

© Chapman & Hall 1994

Authors and Affiliations

  • O. Bermúdez
    • 1
  • M. G. Boltong
    • 1
  • F. C. M. Driessens
    • 1
  • J. A. Planell
    • 1
  1. 1.Departament de Ciència dels Materials i Enginyeria MetallúrgicaUniversitat Politècnica de CatalunyaBarcelonaSpain

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