Cancer Causes & Control

, Volume 3, Issue 1, pp 25–30 | Cite as

Occupation and soft-tissue sarcoma in northeastern Italy

  • Diego Serraino
  • Silvia Franceschi
  • Carlo La Vecchia
  • Antonino Carbone
Research Papers

The influence of occupation and exposure to different agents on the risk of developing soft-tissue sarcoma (STS) was assessed in a case-control study based on 93 cases of STS (53 men and 40 women) and 721 controls (371 men and 350 women), conducted in northeastern Italy. No risk elevation was found in subjects employed in agriculture (odds ratio [OR] for > 10 years = 0.8,95 percent confidence interval [CI]=0.4–1.5), nor in those who reported exposure to pesticides or herbicides (OR=0.4, CI=0.1–1.2). Similarly, neither occupation in the furniture, upholstery, and mechanics industries, nor exposure to livestock or meat processing, wood dust, metal dust, and dyes or paints were associated with STS risk. Workers who reported exposure to chemical agents or to benzene or other solvents for more than 10 years had, respectively, a 1.8-fold (CI=0.7–4.4) and a 2.2-fold (CI=0.9-5.5) higher risk of developing STS. Although the small number of STS cases limits the interpretation of the study results, these findings weigh against the hyphothesis that pesticides, herbicides, or other exposures related to agriculture, play an important role in the etiology of STS. The direct associations with exposure to chemical agents and benzene or other solvents, albeit not statistically significant, may provide a useful hint for future investigations.

Key words

Agriculture benzene case-control study chemicals Italy occupation soft-tissue sarcoma 


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  1. 1.
    Pickle LW, Mason TJ, Howard N, Hoover R, Fraumeni JF. Atlas of US Cancer Mortality Among Whites: 1950–1980. Washington, DC: US Dept of Health and Human Services, Public Health Service, National Institutes of Health, 1987; DHHS Pub. No. (NIH) 87–2900, 180.Google Scholar
  2. 2.
    Levi F, Maisonneuve P, Filiberti R, La Vecchia C, Boyle P. Cancer incidence and mortality in Europe. Soz Praeventivmed 1989; 34 (Suppl. 2): S32-S33.Google Scholar
  3. 3.
    La Vecchia C, Negri E, Decarli A, Fasoli M, and Cislaghi C. Cancer mortality in Italy: an overview of age-specific and age-standardized trends from 1955 to 1984. Tumori 1990; 76: 87–166.Google Scholar
  4. 4.
    Tucker MA, Fraumeni JF. Soft-tissue. In: Schottenfeld D, Fraumeni JFJr, eds. Cancer Epidemiology and Prevention. Philadelphia, PA: WB Saunders Company, 1982: 827–36.Google Scholar
  5. 5.
    Hardell L, Sandstrom A. Case-control study: Soft-tissue sarcomas and exposure to phenoxy acetic acids or chlorophenols. Br J Cancer 1979; 39: 711–17.Google Scholar
  6. 6.
    Eriksson M, Hardell L, Berg NO, Moller T, Axelson O. Soft-tissue sarcomas and exposure to chemical substances: a case-referent study. Br J Ind Med 1981; 38: 27–33.Google Scholar
  7. 7.
    Ott MG, Holder BB, Olson RD. A mortality analysis of employees engaged in the manufacture of 2,4,5,-trichlorophenoxyacetic acid. J Occup Med 1980, 22: 47–50.Google Scholar
  8. 8.
    Milham SJr. Occupational mortality in Washington State 1950–1979. Cincinnati, OH: National Institute for Occupational Safety and Health, 1983; DHHS Pub. No. (NIOSH) 83–116.Google Scholar
  9. 9.
    Wiklund K, Holm LE. Soft-tissue sarcoma risk in Swedish agricultural and forestry workers. JNCI 1986; 76: 229–34.Google Scholar
  10. 10.
    Wiklund K, Dick J, Holm LE. Soft-tissue sarcoma risk in Swedish licensed pesticide applicators. J Occup Med 1988; 30: 801–4.Google Scholar
  11. 11.
    Zahm SH, Blair A, Holmes FF, Boysen CD, Robel RJ, Fraumeni JFJr. A case-control study of soft-tissue sarcoma. Am J Epidemiol 1989; 130: 665–74.Google Scholar
  12. 12.
    Serraino D, Franceschi S, Talamini R, Frustaci S, La Vecchia C. Non-occupational risk factors for adult soft-tissue sarcoma in northern Italy. Cancer Causes Control 1991; 2: 157–64.Google Scholar
  13. 13.
    Enzinger FM, Weiss SW. Soft-tissue Tumors. St Louis, MO: CV Mosby, 1983.Google Scholar
  14. 14.
    Office of Population Census and Surveys. Classification of Occupation 1980. London: HMSO, 1980.Google Scholar
  15. 15.
    Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. JNCI 1959; 22: 719–48.Google Scholar
  16. 16.
    Cornfield J. A statistical problem arising from retrospective studies. In: Neyman J, ed. Proceedings of the Third Berkely Symposium, IV. Berkely, CA: University of California Press, 1956.Google Scholar
  17. 17.
    Mantel N. Chi-square test with one degree of freedom: extension of the Mantel-Haenszel procedure. J Am Stat Assoc 1963; 58: 690–700.Google Scholar
  18. 18.
    Blair A, Malker H, Cantor KP, Burmeister L, Wiklund K. Cancer among farmers. A review. Scand J Work Environ Health 1985; 11: 397–407.Google Scholar
  19. 19.
    Blair A, Zahm SH. Herbicides and cancer: a review and discussion of methodologic issues. In: Band EP, ed. Recent Results in Cancer Research. Occupational Cancer Epidemiology. Berlin-Heidelberg, Germany: Springer-Verlag, 1990; 120: 132–45.Google Scholar
  20. 20.
    Smith AH, Pearce NE, Fisher DO, Giles HJ, Teague CA, Howard JK. Soft-tissue sarcoma and exposure to phenoxyherbicides and chlorophenols in New Zealand. JNCI 1984; 73: 1111–17.Google Scholar
  21. 21.
    Balarajan R, Acheson ED. Soft-tissue sarcomas in agriculture and forestry workers. J Epidemiol Community Health 1984; 38: 113–6.Google Scholar
  22. 22.
    Wang HH, MacMahon B. Mortality of pesticides applicators.. J Occup Med 1979; 21: 741–4.Google Scholar
  23. 23.
    Barthel E. Cancer risk in pesticide-exposed agricultural workers. Arch Geschwulstforsch 1981; 51: 579–85.Google Scholar
  24. 24.
    Hoar SK, Blair A, Holmes F. Agriculture herbicide use and risk of lymphoma and soft-tissue sarcoma. JAMA 1986; 256: 1141–7.Google Scholar
  25. 25.
    Vineis P, Terracini B, Ciccone G, et al. Phenoxy herbicides and soft-tissue sarcomas in female rice weeders. A population based case-referent study. Scand J Work Environ Health 1987; 13: 9–17.Google Scholar
  26. 26.
    Smith AH, Fisher DO, Pearce NE, Teague CA. Do agricultural chemicals cause soft-tissue sarcoma? Initial findings of a case-control study in New Zealand. Community Health Stud 1982; 6: 114–19.Google Scholar
  27. 27.
    Eriksson M, Hardell L, Berg NO, Moller T, Axelson O. Soft-tissue sarcomas and exposure to chemical substances: a case-referent study. Br J Ind Med 1981; 38: 27–33.Google Scholar
  28. 28.
    International Agency for Research on Cancer. Wood, Leather and Some Associated Industries. Lyon, France: IARC, 1981; IARC Monogr Eval Carcinog Risk Chem Humans, Vol. 25.Google Scholar
  29. 29.
    Sterling TD, Stoffman LD, Sterling DA, Mate G. Health effects of chlorophenol wood preservatives on sawmill workers. Int J Health Serv 1982; 12: 559–71.Google Scholar
  30. 30.
    Pearce N, Smith AH, Reif JS. Increased risk of soft tissue sarcoma, malignant lymphoma, and acute myeloid leukemia in abattoir workers. Am J Ind Med 1988; 14(1): 63–72.Google Scholar
  31. 31.
    Stayner LT, Elliot L, Blade L, Keenlyside R, Halperin W. A retrospective cohort mortality study of workers exposed to formaldehyde in the garment industry. Am J Ind Med 1988; 13(6): 667–81.Google Scholar
  32. 32.
    Hardell L, Moss A, Osmond D, Volberding P. Exposure to hair dyes and polychlorinated dibenzo-p-dioxins in AIDS patients with Kaposi's sarcoma: an epidemiological investigation. Cancer Detection Prev 1987; Suppl. 1: 567–70.Google Scholar
  33. 33.
    Bond GG, McLaren EA, Baldwin CL, Cook RR. An update of mortality among chemical workers exposed to benzene. Br J Ind Med 1986; 43: 685–91.Google Scholar
  34. 34.
    Yin SN, Li GL, Tain FD, et al. Leukemia in benzene workers: a retrospective cohort study. Br J Ind Med 1987; 44: 124–8.Google Scholar
  35. 35.
    McCraw DS, Joyner RE, Cole P. Excess leukemia in a refinery population. Occup Med 1985; 27: 220–2.Google Scholar
  36. 36.
    Woods JS, Polissar L, Severson RK, Heuser LS, Kulander BG. Soft-tissue sarcoma and non-Hodgkin's lymphoma in relation to phenoxyherbicide and chlorinated phenol exposure in Western Washington. JNCI 1987; 78: 899–910.Google Scholar
  37. 37.
    Eriksson M, Hardell L, Adami HO. Exposure to dioxins as a risk factor for soft-tissue sarcoma: a population-based case-control study. JNCI 1990; 82: 486–90.Google Scholar
  38. 38.
    Constantini AS, Paci E, Miligi L, Buiatti E, Martelli C, Lenzi S. Cancer mortality among workers in the Tuscan tanning industry. Br J Ind Med 1989; 46(6): 384–8.Google Scholar
  39. 39.
    La Vecchia C, Negri E, D'Avanzo B, Franceschi S. Occupation and lymphoid neoplasms. Br J Cancer 1989; 60: 385–8.Google Scholar
  40. 40.
    Franceschi S, Serraino D, La Vecchia C, Bidoli E, Tirelli U. Occupation and risk of Hodgkin's disease in North-East Italy. Int J Cancer 1991; 48: 831–5.Google Scholar

Copyright information

© Rapid Communications of Oxford Ltd 1992

Authors and Affiliations

  • Diego Serraino
  • Silvia Franceschi
  • Carlo La Vecchia
  • Antonino Carbone

There are no affiliations available

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