Cancer and Metastasis Reviews

, Volume 15, Issue 1, pp 113–118

Clinical studies in head and neck cancer chemoprevention

  • Pablo M. Gonzalez
  • Steven E. Benner

Abstract

Secondary neoplasms represent a major threat for patients with head and neck cancer. The prevention of secondary neoplasms has been a major goal of head and neck cancer chemoprevention efforts. In order to help develop effective strategies, reversal of oral premalignancy has been used as a model for chemoprevention. There is now sufficient data to show the chemopreventive effect in premalignant lesions of some natural compounds and their derivatives. Retinoids are the most studied chemopreventive agents for the treatment of oral leukoplakia. Other compounds with chemopreventive activity are carotenoids, Vitamin E derivatives and Selenium. There are two large prospective, randomized, chemoprevention clinical trials, one in Europe and the other in North America, using prevention of secondary malignancy as the primary study end-point. Until these trials are completed, the use of chemoprevention in head and neck cancer should be limited to clinical trials.

Key words

chemoprevention head and neck cancer retinoids secondary neoplasms 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • Pablo M. Gonzalez
    • 1
  • Steven E. Benner
    • 1
  1. 1.Division of Hematology/OncologyUniversity of North Carolina at Chapel HillUSA
  2. 2.UNCChapel HillUSA

Personalised recommendations