Advertisement

Journal of Applied Phycology

, Volume 1, Issue 3, pp 257–266 | Cite as

Isolation of an unknown kainic peptide from the red algaAlsidium helminthocorton

  • R. Calaf
  • A. Barlatier
  • D. Garçon
  • G. Balansard
  • M. Pellegrini
  • J. Reynaud
Article

Abstract

A study ofAlsidium helminthocorton Kütz. (Rhodophyceae) an alga with anti-helminthic activity, led to the separation of free imino-acids identified by IR and1H-NMR spectroscopy as alpha-kainic acid, alpha-kainic acid lactone and alpha-allokainic acid. In addition, a novel peptide was isolated, of 37 amino-acids including two kainic acid residues in its sequence.

Key words

imino-acids alpha-kainic acid kainic peptide Alsidium helminthocorton Corsican Moss 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Balansard G, Pellegrini M, Cavalli C, Timon-David P, Gasquet M (1983) Diagnose et action anti-helminthique de la Mousse de CorseAlsidium helminthocorton Kützing, deJania rubens Lamour, etCorallina officinalis L. Ann. Ph. Fr. 41: 77–86.Google Scholar
  2. Bladon P (1969) General review of proton magnetic resonance. In: Mooney EF (ed.), Annual Review of NMR Spectroscopy. Academic Press, London and New York, 2: 1–33.Google Scholar
  3. Casy AF (1971) Application of PMR spectroscopy to stereochemical problems. In: PMR Spectroscopy in Medicinal and Biological Chemistry. Academic Press, London and New York, 93–132.Google Scholar
  4. McGeer PL, McGeer EG, Hattori T (1978) Kainic acid as a tool in neurobiology. In: McGeer EG, Olney JW, McGeer PL (eds), Kainic Acid as a Tool in Neurobiology. Raven Press, New York, 123–138.Google Scholar
  5. Miyasaki M, Watanabe H, Nakano M, Takano T, Morimoto H (1955) Studies on the components ofDigenea simplex Ag. I. Studies on the structure of kainic acid, the antihelminthic component. J. Pharm. Soc. Japan. 75: 72–79.Google Scholar
  6. Miyasaki M, Watanabe H, Takano T, Akira H (1956) Studies on the components ofDigenea simplex Ag. VII. Studies on the related compounds of kainic acid. J. Pharm. Soc. Japan. 76: 189–191.Google Scholar
  7. Morimoto H, Nakamori R (1956) Studies on the active components ofDigenea simplex Ag. and related compounds. XXXVI. Isomerization and isomers of kainic acid (15). Stereochemical configuration of kainic acid and its derivatives (3). J. Pharm. Soc. Japan. 76: 294–298.Google Scholar
  8. Murakami S, Takemoto T, Shimizu Z (1953) Studies on the effective principles ofDigenea simplex Ag. I. Separation of the effective fraction by liquid chromatography. J. Pharm. Soc. Japan. 73: 1026–1027.Google Scholar
  9. Murakami S, Takemoto T, Tei Z, Daigo K, Takagi N (1955) Studies on the effective principles ofDigenea simplex Ag. X. On alpha-allokainic acid. J. Pharm. Soc. Japan. 75: 1252–1257.Google Scholar
  10. Shinozaki H (1978) Discovery of novel actions of kainic acid and related compounds. In: McGeer EG, Olney JW, McGeer PL (eds), Kainic Acid as a Tool in Neurobiology. Raven Press, New York, 17–35.Google Scholar
  11. Takemoto T, Tei Z, Daigo K (1956) Studies on the effective principles ofDigenea simplex Ag. XII. Stereochemical structures of kainic acid and alpha-allokainic acid. J. Pharm. Soc. Japan. 76: 298–300.Google Scholar

Copyright information

© Kluwer Academic Publishers 1989

Authors and Affiliations

  • R. Calaf
    • 1
  • A. Barlatier
    • 1
  • D. Garçon
    • 1
  • G. Balansard
    • 2
  • M. Pellegrini
    • 3
  • J. Reynaud
    • 1
  1. 1.Laboratoires de Chimie Biologique et de PharmacognosieMarseille Cedex 5France
  2. 2.Faculté de PharmacieMarseille Cedex 5France
  3. 3.Laboratoire de Biologie Marine Fondamentale et AppliquéeFaculté des Sciences de LuminyMarseille Cedex 9France

Personalised recommendations