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Cytotoxic effect of a polymer–copper(II) complex containing 2,2′-bipyridyl ligand on human lung cancer cells

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Abstract

The cytotoxic activity of the polymer–copper(II) complex, [Cu(bpy)2(BPEI)]Cl2·4H2O (bpy = 2,2′-bipyridine, BPEI = branched polyethyleneimine) on NCI-H460 human lung cancer cells was determined adopting MTT assay and specific staining techniques. Many of the cultured NCI-H460 cancer cells treated with this complex suffered loss of viability and death mostly through apoptosis and/or necrosis as evidenced by the changes in the nuclear morphology and cytoplasmic features.

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Acknowledgements

The DST-FIST and UGC-SAP support for improvement of infrastructure facility at Animal Science Department of Bharathidasan University, and the UGC-SAP, COSIST, and DST-FIST programmes offered to the School of Chemistry are gratefully acknowledged.

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Authors and Affiliations

  1. Laboratory of Photomedicine, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

    R. Senthil Kumar

  2. Department of Animal Science, Bharathidasan University, Tiruchirappalli, 620 024, India

    V. S. Periasamy, C. Preethy Paul, A. Riyasdeen & M. A. Akbarsha

  3. Department of Chemistry, Bharathidasan University, Tiruchirappalli, 620 024, India

    S. Arunachalam

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  1. R. Senthil Kumar
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  2. V. S. Periasamy
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  3. C. Preethy Paul
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  4. A. Riyasdeen
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  5. S. Arunachalam
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  6. M. A. Akbarsha
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Correspondence to S. Arunachalam.

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Senthil Kumar, R., Periasamy, V.S., Preethy Paul, C. et al. Cytotoxic effect of a polymer–copper(II) complex containing 2,2′-bipyridyl ligand on human lung cancer cells. Med Chem Res 20, 726–731 (2011). https://doi.org/10.1007/s00044-010-9380-8

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  • DOI: https://doi.org/10.1007/s00044-010-9380-8

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