Summary
The fine structure of the small blood vessels in chromophobe adenoma was compared to normal pituitary. The most striking difference was the relative paucity of endothelial fenestrae in the tumor accompanied by a widened perivascular space. The origin of these changes and their possible functional significance are discussed.
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Bennett, H. S., Luft, J. H., Hampton, J. C.: Morphological classification of vertebrate blood capillaries. Amer. J. Physiol.196, 381–390 (1959).
Bergland, R. M., Torack, R. M.: An ultrastructural study of follicular cells in the human anterior pituitary. Amer. J. Path.57, 273–297 (1969).
Cardell, R. R., Knighton, R. S.: The cytology of a human pituitary tumor: An electron microscopic study. Trans. Amer. micr. Soc.85, 58–78 (1966).
Farquhar, M. G.: Fine structure and function in capillaries of the anterior pituitary gland. Angiology12, 270–292 (1961).
Fukumitsu, T.: Electron microscopic study of the human pituitary adenomas. Arch. jap. Chir.33, 329–349 (1964).
Gusek, W.: Vergleichende licht- und elektronenmikroskopische Untersuchungen menschlicher Hypophysenadenome bei Akromegalie. Endokrinologie42, 257–283 (1962).
Hirano, A., Zimmerman, H. M., Levine, S.: The fine structure of cerebral fluid accumulation. III. Extracellular spread of cryptococcal polysaccharides in the acute stage. Amer. J. Path.45, 1–19 (1964).
———: The fine structure of cerebral fluid accumulation. IX. Edema following silver nitrate implantation. Amer. J. Path.47, 537–548 (1965).
Luse, S.: Ultrastructure characteristics of normal and neoplastic cells. Progr. exp. Tumor Res. (Basel)2, 1–35 (1961).
Matsuda, H., Sugiura, S.: Ultrastructure of “tubular body” in the endothelial cells of the ocular blood vessels. Invest. Ophthal.9, 919–925 (1970).
Oliva, H., Navarro, V., Obrador, S.: Microscópico electrónica de los adenomas cromófobos de la hipófisis. Acta neurochir. (Wien)14, 141–153 (1966).
Poon, T. P., Hirano, A., Zimmerman, H. M.: Electron microscopic atlas of brain tumors. New York: Grune & Stratton 1971.
Porter, K. R., Bonneville, M. A.: Fine structure of cells and tissues. Philadelphia: Lea & Feibiger 1968.
Rinehart, J. F., Farquhar, M. G.: The fine vascular organization of the anterior pituitary gland. Anat. Rec.121, 207–239 (1955).
Salazar, H., MacAulay, M. A., Charles, D., Pardo, M.: The human hypophysis in anancephaly. I. Ultrastructure of the pars distalis. Arch. Path.87, 201–211 (1969).
Schelin U.: Chromophobe and acidophil adenomas of the human pituitary gland. A light and electron microscopic study. Acta path. microbiol. scand. Suppl.158, 5–80 (1962).
Wechsler, W., Hossmann, K. A.: Elektronenmikroskopische Untersuchungen chromophober Hypophysen-Adenoma des Menschen. Zbl. Neurochir.26, 105–122 (1965).
Weibel, E. R., Palade, G. E.: New cytoplasmic components in arterial endothelia. J. Cell Biol.23, 101–112 (1964).
Zambrano, D., Amezua, L., Dickmann, G., Franke, E.: Ultrastructure of human pituitary adenoma. Acta neurochir. (Wien)18, 78–94 (1968).
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Hirano, A., Tomiyasu, U. & Zimmerman, H.M. The fine structure of blood vessels in chromophobe adenoma. Acta Neuropathol 22, 200–207 (1972). https://doi.org/10.1007/BF00684523
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DOI: https://doi.org/10.1007/BF00684523