Bulletin of Mathematical Biology

, Volume 60, Issue 3, pp 477–503 | Cite as

Models for the length distributions of actin filaments: II. Polymerization and fragmentation by gelsolin acting together

  • G. Bard Ermentrout
  • Leah Edelstein-Keshet


In a previous paper, we studied elementary models for polymerization, depolymerization, and fragmentation of actin filaments (Edelstein-Keshet and Ermentrout, 1998, Bull. Math. Biol. 60, 449–475). When these processes act together, more complicated dynamics occur. We concentrate on a particular case study, using the actin-fragmenting protein gelsolin. A set of biological parameter values (drawn from the experimental literature) is used in computer simulations of the kinetics of gelsolin-mediated actin filament fragmentation.


Actin Filament Barb Length Distribution Actin Monomer Fragmin 
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Copyright information

© Society for Mathematical Biology 1998

Authors and Affiliations

  • G. Bard Ermentrout
    • 1
  • Leah Edelstein-Keshet
    • 2
  1. 1.Department of MathematicsUniversity of PittsburghPittsburghUSA
  2. 2.Department of MathematicsUniversity of British ColumbiaVancouverCanada

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