Estimating the size of the olfactory repertoire
- 45 Downloads
The concept of shape space, which has been successfully implemented in immunology, is used here to construct a model for the discrimination power of the olfactory system. Using reasonable assumptions on the behaviour of the biological system, we are able to estimate the number of distinct olfactory receptor types. Our estimated value of around 1000 receptor types is in good agreement with experimental data.
KeywordsOlfactory System Discrimination Power Shape Space Single Receptor Immune Network
Unable to display preview. Download preview PDF.
- Borghans, J. A. M., A. J. Noest and R. J. De Boer (1999). How specific should immunological memory be? J. Immunol. 163, 569–575.Google Scholar
- Cohen, I. R. (2000). Tending Adam’s Garden, Academic Press.Google Scholar
- De Boer, R. J. and A. S. Perelson (1991). Size and connectivity as emergent properties of developing immune network. J. Theor. Biol. 149, 381–424.Google Scholar
- Janeway, C. and P. Travers (1997). Immunobiology: the Immune System in Health and Disease, 3rd edn, Current Biology Ltd., Garland.Google Scholar
- Kohonen, T. (1997). Self-organizing Maps, 2nd edn, Springer.Google Scholar
- Mori, K. and Y. Yoshihara (1998). Molecular recognition and olfactory processing in the mammlian olfactory system. Prog. Neurobiol. 13, 479–493.Google Scholar
- Segel, L. A. and A. S. Perelson (1988). Computations in shape space: a new approach to immune network theory, in Theoretical Immunology Part Two, SFI Studies in the Sciences of Complexity, A. Perelson (Ed.), Addison-Wesley Publishing Company, pp. 321–343.Google Scholar