Overview
- Covers the most recent developments in the analysis of allosteric enzymes
- Extensively illustrated to clarify kinetic and regulatory properties
- Discusses recently created crystal structures of the enzymes
- Provides a detailed enzyme structure for each enzyme covered in the book
- Focuses on the features of these enzymes that are invaluable to the discussion of allosterism and regulation
- Includes supplementary material: sn.pub/extras
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About this book
All enzymes are remarkable since they have the ability to increase the rate of a chemical reaction, often by more than a billion-fold. Allosteric enzymes are even more amazing because the have the additional ability to change their rate in response to cellular activators or inhibitors. This enables them to control the pathway in which they are the regulatory enzyme. Since the effector molecules represent the current status of the cell for a given metabolic pathway, this results in very responsive and balanced metabolic states, and makes it possible for cells and organisms to be appropriately dynamic, and responsive, in a changing environment. This book provides a logical introduction to the limits for enzyme function as dictated by the factors that are limits for life. This book presents a complete description of all the mechanisms used for changing enzyme acticity. Eight enzymes are used as model systems after extensive study of their mechanisms. Wherever possible, the human form of the enzyme is used to illustrate the regulatory features.
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Keywords
Table of contents (13 chapters)
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Overview Of Enzymes
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K-Type Enzymes
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V-Type Enzymes
Reviews
From the reviews:
"This holistic introduction to enzymes in general covers the history of their discovery and the different mechanisms of action before going into an in-depth presentation of particular allosteric enzymes and enzyme families. … This book will be of great help to graduate students and postdoctoral fellows interested in understanding the theory behind the action of allosteric enzymes. … an excellent book of enzymology focusing on the mechanisms employed by allosteric enzymes and their metabolic regulation." (Helen Anni, Doody’s Review Service, October, 2008)
Authors and Affiliations
About the author
Thomas Traut has a PhD in molecular biology and has studied enzymes since 1974. As a professor at the University of North Carolina at Chapel Hill, he has focused on enzyme regulation and taught advanced enzymology to graduate students. Important findings from his research helped to define the mechanism of allosteric control for dissociating enzymes.
Bibliographic Information
Book Title: Allosteric Regulatory Enzymes
Authors: Thomas Traut
DOI: https://doi.org/10.1007/978-0-387-72891-9
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer-Verlag US 2008
Hardcover ISBN: 978-0-387-72888-9Published: 07 November 2007
Softcover ISBN: 978-1-4419-4453-5Published: 04 November 2010
eBook ISBN: 978-0-387-72891-9Published: 11 September 2007
Edition Number: 1
Number of Pages: XIV, 250
Topics: Enzymology, Biochemistry, general, Biomedical Engineering and Bioengineering, Cell Biology, Chemistry/Food Science, general, Biomedicine general