Abstract
Background
The pathogenesis of chronic obstructive pulmonary disease (COPD) is multifactorial; oxidative stress is suggested to be one of the pathogenetic factors.
Objective
The aim of this study was to assess the role of antioxidant status in pathogenesis of COPD and in predicting the severity of airway obstruction.
Patients and methods
This case-controlled study was carried on 60 patients with COPD, and on 15 apparently healthy age-matched smokers and 15 apparently healthy age-matched nonsmokers, which served as control groups. Bronchoscopy with bronchoalveolar lavage was carried out for 10 COPD patients. Chest radiography, pulmonary function testing, and arterial blood gases were carried out for all groups. Serum level of total antioxidant (TAO) was also measured in all groups by using the enzyme-linked immunosorbent assay kit.
Results
Serum TAO level was significantly reduced in COPD patients and healthy smokers compared with healthy nonsmokers (P<0.001, respectively); moreover, serum TAO level was significantly reduced in COPD compared with healthy smokers (P<0.001), and serum TAO was significantly reduced in severe and very severe COPD compared with mild and moderate COPD (P=0.01 and 0.006, respectively). TAO level significantly negatively correlated with each of PaCO2 and HCO3 in COPD patients, and it was significantly positively correlated with each of forced expiratory volume in 1 s/forced vital capacity and forced expiratory volume in 1 s %. TAO had a sensitivity and specificity of 86.67 and 93.33, respectively, as a biomarker for identification and predicting the severity of COPD with an area under the curve of 0.921.
Conclusion
Serum TAO is a valuable biomarker in identifying and predicting the severity of COPD.
Article PDF
Similar content being viewed by others
References
GOLD. Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease. GOLD; 2016.
Yoshida T, Tuder RM. Pathobiology of cigarette smoke induced chronic obstructive pulmonary disease. Physiol Rev 2007; 87:1047–1082.
Anderson D, Macnee W. Targeted treatment in COPD: a multi-system approach for a multi-system disease. Int J Chron Obstruct Pulmon Dis 2009; 4:321–325.
Tavilani H, Nadi E, Karimi J, Taghi M. Oxidative stress in COPD patients, smokers, and non-smokers. Respir Care 2012; 57:2090–2094.
Zeng M, Li Y, Jiang Y, Lu G, Huang X, Guan K. Local and systemic oxidative stress and glucocorticoid receptor in chronic obstructive pulmonary disease patients. Can Respir J 2012: 35–41.
Van Eeden SF, Leipsic J, Man SF, Sin DD. The relationship between lung inflammation and cardiovascular disease. Am J Respir Crit Care Med 2012; 186:11–16.
Kido T, Tamagawa E, Bai N, Suda K, Yang HH, Li Y, et al. Particulate matter induces translocation of IL-6 from the lung to the systemic circulation. Am J Respir Cell Mol Biol 2011; 44:197–204.
Abdel-Wahab BA, Salama RH. Venlafaxine protects against stress-induced oxidative DNA damage in hippocampus during antidepressant testing in mice. Pharmacol Biochem Behav 2011; 100:59–65.
Vestbo J, Hurd S, Agustí A, Jones P, Vogelmeier C, Anzueto A. Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease, GOLD executive summary. Am J Respir Crit Care Med 2012; 176:532–555.
Pallasaho P, Meren M, Raukas-Kivioja A, Rönmark E. Not 15 but 50% of smokers develop COPD? Report from the obstructive lung disease in northern Sweden studies. Respir Med 2003; 97:8.
Burney PGJ, Patel J, Newson R, Minelli C, Naghavi M. Global and regional trends in COPD mortality, 1990–2010, Eur Respir J 2015; 45:1239–1247.
Brusselle GG, Joos GF, Bracke KR. New insights into the immunology of chronic obstructive pulmonary disease, Lancet 2015; 378:1015–1026.
Ambade V, Sontakka A, Basannar D. Total antioxidant capacity: Correlation with other antioxidants and clinical utility of their levels in chronic obstructive pulmonary disease. Int J Biochem Res Rev 2014; 4:150–162.
Mohamed NA, EL-Deek SEM, Makhlouf HA, Ahmed Y, EL-Metwaly T. Role of hypoxia inducible factor-1α, vascular endothelial growth factor and total antioxidant capacity in chronic obstructive pulmonary disease. Med J Cairo Univ 2015; 8:435–441.
Emin S, Yordanoval K, Dimov D, Vlaykova T. Total antioxidant determined as ferrous reducing ability of plasma in patients with COPD. Trakia J Sci. 2010; 8:205–213.
Rahman I,Swarska E,Henry M,MacNee W. Is there any relationship between plasma antioxidant capacity and lung function in smokers and in patients with chronic obstructive pulmonary disease? Thorax 2010; 55:189–193.
Sahin U, Unlu M, Ozguner F, Sutcu R, Akkaya A, Delibas N. Lipid peroxidation and glutathione peroxidase activity in chronic obstructive pulmonary disease exacerbation prognostic value of malondialdehyde. J Basic Clin Physiol Pharmacol 2001; 12:59–68.
Olivieri S, Conti A, Iannaccone S, Cannistraci C, Campanella A, Barbariga M, et al. Ceruloplasmin oxidation, a feature of Parkinson’s disease CSF, inhibit ferrooxidase activity and promotes cellular iron retention. J Neurosci 2011; 31:18568–18577.
Salvi S, Barnes PJ. Chronic obstructive pulmonary disease in non smokers. Lancet 2009; 374:733–743.
Kontakiotis T, Katsoulis K, Hagizisi O, Kougioulis M, Gerou S, Papakosta D. Bronchoalveolar lavage fluid alteration in antioxidant and inflammatory status in lung cancer patients. Eur J Intern Med 2011; 22:522–526.
Author information
Authors and Affiliations
Corresponding author
Additional information
This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work noncommercially, as long as the author is credited and the new creations are licensed under the identical terms.
Rights and permissions
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
About this article
Cite this article
Salama, R.H.M., Elkholy, M.M., Sadek, S.H. et al. Total antioxidant capacity as a marker in predicting severity of chronic obstructive pulmonary diseases. Egypt J Bronchol 11, 322–326 (2017). https://doi.org/10.4103/1687-8426.217638
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.4103/1687-8426.217638