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Methamphetamine and lentivirus interactions: Reciprocal enhancement of central nervous system disease

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Abstract

Use of methamphetamine is increasingly a significant factor for the spread of human immunodeficiency virus type 1, for in certain populations, there is a convergence of methamphetamine abuse with human immunodeficiency virus type 1 infection. Methamphetamine and human immunodeficiency virus type 1 are both individually neuropathogenic, and the neuropathology caused by these two agents occurs in overlapping brain regions. However, the biological interaction of methamphetamine with lentiviruses remains unknown. Here, we investigate the effects of simultaneous exposure of these two agents on disease progression using the feline immunodeficiency virus model. The study models the bingeing methamphetamine user with sequential and repeatedepisodes of use, which were interrupted by periods of abstinence. Methamphetamine exposure significantly accelerated and enhanced the severity of the feline immunodeficiency virus model-induced central nervous system functional pathology, as measured in delays in brainstem auditory evoked potentials. Reciprocally, feline immunodeficiency virus enhanced the severity of the methamphetamine-induced effects on brain monoamine neurotransmitter and dopamine transporter levels. The results of this study indicate that a dual potentiation occurred. That is, methamphetamine enhanced feline immunodeficiency virus model—induced central nervous system disease and feline immunodeficiency virus model enhanced the toxic effects of methamphetamine, heralding a significant concern for those individuals that are exposed to both agents.

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Authors and Affiliations

  1. Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California, USA

    Salvador Huitron-Resendiz & Manuel Sanchez-Alavez

  2. Graduate College Biomedical Sciences and College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, California, USA

    Steven J. Henriksen

  3. College of Veterinary Medicine, Graduate College of Biomedical Sciences, Western University of Health Sciences, 309 Second Street, 91766, Pomona, CA, USA

    Margaret C. Barr, Maria P. Testa & Tom R. Phillips

  4. Committee of Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California, USA

    Elena Crawford & Loren H. Parsons

Authors
  1. Salvador Huitron-Resendiz
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  2. Steven J. Henriksen
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  3. Margaret C. Barr
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  4. Maria P. Testa
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  5. Elena Crawford
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  6. Loren H. Parsons
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  7. Manuel Sanchez-Alavez
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  8. Tom R. Phillips
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Correspondence to Tom R. Phillips.

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This work is supported by NIH (P01 DA12444-03/SJH and R24 RR10712/TRP).

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Huitron-Resendiz, S., Henriksen, S.J., Barr, M.C. et al. Methamphetamine and lentivirus interactions: Reciprocal enhancement of central nervous system disease. Journal of NeuroVirology 16, 268–278 (2010). https://doi.org/10.3109/13550284.2010.497807

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