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Universal Production Technology of Virus-Containing Material for Manufacturing Live and Inactivated Vaccines against Especially Dangerous Livestock Infections

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Abstract

A universal technology for obtaining virus-containing raw material used in the manufacture of vaccine preparations against plague in small ruminants, sheep pox, goat pox, bluetongue disease, and orf (contagious pustular dermatitis) of cattle has been described. The epizootic situation in the Russian Federation and neighboring countries in respect to these diseases, which pose the greatest danger for the introduction of a virus from their territory, has been analyzed. The main technological parameters used in the production of highly active viral raw material required for the manufacture of vaccine preparations are presented. It has been shown that, in the obtained transplantable sublines of cell cultures of sheep kidney and saiga kidney, which are interchangeable, it is possible in one production cycle to obtain 48 dm3 of vaccinated material with an activity of 5.58–6.67 log TCD50/cm3, from which one can produce from 4.5 to 9.0 million doses of vaccine. When using vaccines prepared on the basis of the described technology, the animals developed intense immunity to the indicated diseases.

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Funding

The research was carried out within the framework of state assignment no. 0451-2019-0005

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Authors and Affiliations

  1. Federal Research Center of Virology and Microbiology, 601125, Volginsky, Vladimir oblast, Russia

    V. M. Balyshev, S. G. Yurkov, V. I. Balysheva, O. G. Lapteva, I. A. Slivko, S. P. Zhivoderov & A. V. Lunitsin

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  1. V. M. Balyshev
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  2. S. G. Yurkov
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  3. V. I. Balysheva
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  4. O. G. Lapteva
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  5. I. A. Slivko
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  6. S. P. Zhivoderov
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  7. A. V. Lunitsin
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Corresponding author

Correspondence to V. M. Balyshev.

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In carrying out this work, all ethical standards were observed.

Conflict of interest. The authors declare that they have no conflict of interest.

This work does not contain a description of any studies using humans and animals as objects.

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Translated by A. Ostyak

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Balyshev, V.M., Yurkov, S.G., Balysheva, V.I. et al. Universal Production Technology of Virus-Containing Material for Manufacturing Live and Inactivated Vaccines against Especially Dangerous Livestock Infections. Russ. Agricult. Sci. 46, 525–529 (2020). https://doi.org/10.3103/S1068367420050031

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  • DOI: https://doi.org/10.3103/S1068367420050031

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