Abstract
The results of the study demonstrated the immunosuppression in albino rats under a complex impact of T-2 toxin and Salmonella, manifested by the significant increase of anti-inflammatory cytokine IL-1β content in the blood and a slight increase of IL-4, stimulating the humoral immunity, the decrease of concentration of other anti-inflammatory mediators (TNF-α, IL-8), immunoregulatory interleukins IL-2, interferon-γ and anti-inflammatory cytokine IL-10, and interferon–γ/IL-4 ratio, indicating an evident T-deficit and a more significant suppression of Th-1 lymphocyte function.
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Original Russian Text © A.G. Shakhov, L.Yu. Sashnina, Yu.N. Mas’yanov, G.A. Vostroilova, 2016, published in Rossiiskaya Sel’skokhozyaistvennaya Nauka, 2016, Nos. 2–3, pp. 50–53.
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Shakhov, A.G., Sashnina, L.Y., Mas’yanov, Y.N. et al. Cytokine profile of albino rats’ changes under the impact of Salmonella against the background of subacute T-2 toxicosis. Russ. Agricult. Sci. 42, 271–274 (2016). https://doi.org/10.3103/S1068367416030198
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DOI: https://doi.org/10.3103/S1068367416030198