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Effect of Magnetite Nanoparticle Morphology on the Parameters of MRI Relaxivity

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Bulletin of the Russian Academy of Sciences: Physics Aims and scope

Abstract

Results are presented from synthesizing and characterizing magnetite nanoparticles with spherical, cubic and octahedral geometry. Magnetic properties (saturation magnetization, residual magnetization, and coercive force), cytotoxicity, and T2 relaxivity are measured for the synthesized nanoparticles. They are characterized via X-ray diffraction and dynamic light scattering (hydrodynamic size and zeta potential). The effect the shape of the nanoparticles have on the values of T2 relaxivity is analyzed. Nontoxic magnetite nanoparticles coated with copolymer are excellent contrast agents for magnetic resonance imaging (MRI) and show better contrast properties than their commercial analogs (Rezovist, Ferumoxytol, Feridex).

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Authors and Affiliations

  1. National University of Science and Technology MISiS, Moscow, 119049, Russia

    T. L. Nguyen, T. R. Nizamov, M. A. Abakumov, I. V. Shchetinin, A. G. Savchenko & A. G. Majouga

  2. Moscow State University, Moscow, 119991, Russia

    A. G. Majouga

  3. Pirogov National Research Medical University, Moscow, 117997, Russia

    M. A. Abakumov

  4. Mendeleev University of Chemical Technology, Moscow, 125047, Russia

    A. G. Majouga

Authors
  1. T. L. Nguyen
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  2. T. R. Nizamov
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  3. M. A. Abakumov
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  4. I. V. Shchetinin
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  5. A. G. Savchenko
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  6. A. G. Majouga
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Corresponding author

Correspondence to T. L. Nguyen.

Additional information

Original Russian Text © T.L. Nguyen, T.R. Nizamov, M.A. Abakumov, I.V. Shchetinin, A.G. Savchenko, A.G. Majouga, 2018, published in Izvestiya Rossiiskoi Akademii Nauk, Seriya Fizicheskaya, 2018, Vol. 82, No. 9, pp. 1335–1342.

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Nguyen, T.L., Nizamov, T.R., Abakumov, M.A. et al. Effect of Magnetite Nanoparticle Morphology on the Parameters of MRI Relaxivity. Bull. Russ. Acad. Sci. Phys. 82, 1214–1221 (2018). https://doi.org/10.3103/S1062873818090150

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  • DOI: https://doi.org/10.3103/S1062873818090150

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