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RNA import into mitochondria and its use in gene therapy

  • Molecular Biology
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Abstract

Among the biological macromolecules imported into the mitochondria of eukaryotic cells, there are proteins and ribonucleic acids. Protein import into mitochondria is a universal process, and its mechanisms are currently well described. RNA import into mitochondria, on the contrary, is known only for several eukaryotic species, and the mechanisms of this process are largely species specific. In this review, we summarize the existing data about the RNA import into mitochondria of human cells and discuss the possibilities of its implication for the gene therapy of mitochondrial diseases.

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Authors and Affiliations

  1. Department of Biology, Moscow State University, Moscow, 119992, Russia

    V. A. Lakunina, M. V. Baleva, S. A. Levitskii, I. V. Chicherin, I. A. Krasheninnikov, E. O. Samoylova & P. A. Kamenski

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  1. V. A. Lakunina
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  2. M. V. Baleva
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  3. S. A. Levitskii
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  4. I. V. Chicherin
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  5. I. A. Krasheninnikov
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  6. E. O. Samoylova
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  7. P. A. Kamenski
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Corresponding author

Correspondence to V. A. Lakunina.

Additional information

Original Russian Text © V.A. Lakunina, M.V. Baleva, S.A. Levitskii, I.V. Chicherin, I.A. Krasheninnikov, E.O. Samoylova, P.A. Kamenski, 2015, published in Vestnik Moskovskogo Universiteta. Biologiya, 2015, No. 3, pp. 32–36.

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Lakunina, V.A., Baleva, M.V., Levitskii, S.A. et al. RNA import into mitochondria and its use in gene therapy. Moscow Univ. Biol.Sci. Bull. 70, 132–135 (2015). https://doi.org/10.3103/S0096392515030062

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  • DOI: https://doi.org/10.3103/S0096392515030062

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