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Thirty years after the Chernobyl accident: Molecular genetic mechanisms of carcinogenesis of the thyroid gland

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Abstract

The review presents data on the basic molecular genetic mechanisms of formation of papillary thyroid carcinoma. The participation of ionizing radiation in the cancer pathogenesis was analyzed. The role of tumor microenvironment, inflammation, and nuclear transcription factor NF-κB in the initiation and development of papillary thyroid carcinoma was shown.

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Authors and Affiliations

  1. Komisarenko Institute of Endocrinology and Metabolism, National Academy of Medical Sciences of Ukraine, Kyiv, 04114, Ukraine

    N. D. Tronko & V. M. Pushkarev

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  1. N. D. Tronko
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  2. V. M. Pushkarev
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Correspondence to V. M. Pushkarev.

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Original Russian Text © N.D. Tronko, V.M. Pushkarev, 2016, published in Tsitologiya i Genetika, 2016, Vol. 50, No. 6, pp. 15–22.

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Tronko, N.D., Pushkarev, V.M. Thirty years after the Chernobyl accident: Molecular genetic mechanisms of carcinogenesis of the thyroid gland. Cytol. Genet. 50, 366–371 (2016). https://doi.org/10.3103/S0095452716060098

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  • DOI: https://doi.org/10.3103/S0095452716060098

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