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The relationship between NO-synthase inhibitory activity of N,S-containing heterocycles and their radioprotective and antileukemic properties

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Moscow University Chemistry Bulletin Aims and scope

Abstract

The effect of NO-synthase (NOS) activator and inhibitors on leukemic cell lines HL-60, K-562, and MOLT-4 and bone marrow cells of untreated patients diagnosed with B-cell acute lymphoblastic leukemia compared with lymphocytes from healthy donors is examined. The obtained data on the relationships between the radioprotective, NOS inhibitory, and cytotoxic properties of a number of thiazine, thiazoline, and thiourea derivatives indicates their potential for use as agents for complex radio- and chemotherapy.

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Authors and Affiliations

  1. Department of Chemistry, Moscow State University, Moscow, Russia

    M. A. Orlova, T. P. Trofimova & A. P. Orlov

  2. Rogachev Federal Scientific Clinical Centre of Pediatric Hematology, Oncology and Immunology, Moscow, Russia

    M. A. Orlova, T. P. Trofimova & S. V. Nikulin

  3. Moscow Institute of Physics and Technology, Moscow, Russia

    S. V. Nikulin

  4. Scientific Centre for Expertise of Medical Products, Russian Ministry of Health, Moscow, Russia

    A. P. Orlov

Authors
  1. M. A. Orlova
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  2. T. P. Trofimova
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  3. S. V. Nikulin
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  4. A. P. Orlov
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Corresponding author

Correspondence to M. A. Orlova.

Additional information

Original Russian Text © M.A. Orlova, T.P. Trofimova, S.V. Nikulin, A.P. Orlov, 2016, published in Vestnik Moskovskogo Universiteta, Seriya 2: Khimiya, 2016, No. 4, pp. 270–275.

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Orlova, M.A., Trofimova, T.P., Nikulin, S.V. et al. The relationship between NO-synthase inhibitory activity of N,S-containing heterocycles and their radioprotective and antileukemic properties. Moscow Univ. Chem. Bull. 71, 258–262 (2016). https://doi.org/10.3103/S0027131416040052

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  • DOI: https://doi.org/10.3103/S0027131416040052

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