Abstract
Doxorubicin-containing micro- and nanoparticles obtained by layer-by-layer adsorption of dextran sulfate and chitosan on an insoluble antibiotic–polyanion complex with subsequent sonication were studied. The effects of the molecular mass of biopolymers, the number of polyelectrolyte layers, and the pH of the reaction medium on the composition, physicochemical properties, and the efficiency of doxorubicin incorporation have been examined. The release of doxorubicin and the mucoadhesive properties of the polyelectrolyte particles have been analyzed to determine the possibilities of their potential applications.
Similar content being viewed by others
References
Tacar, O., Sriamornsak, P., Crispin, R., and Dass, C.R., J. Pharm. Pharmacol., 2013, vol. 65, p. 157.
Santos, R., Cardoso, S., Correia, S., Oliveira, P.J., Santos, M.S., and Moreira, P.I., Curr. Med. Chem., 2009, vol. 16, no. 25, p. 3267.
Yousefpour, P., Atyabi, F., Farahani, E.V., Sakhtianchi, R., and Dinarvand, R., Int. J. Nanomed., 2011, vol. 6, p. 1487.
Tan, M.L., Choong, P.F.M., and Dass, C.R., J. Pharm. Pharmacol., 2009, vol. 61, p. 131.
Sanyakamdhorn, S., Agudelo, D., and TajmirRiahi, H.A., Biomacromolecules, 2013, vol. 14, p. 557.
Balabushevich, N.G., Izumrudov, V.A., and Larionova, N.I., Polym. Sci., Ser. A, 2012, vol. 54, no. 7, p. 540.
Balabushevich, N.G., Pechenkin, M.A., Lopes de Gerenyu, A.V., Zorov, I.N., Mikhal’chik, E.V., and Larionova, N.I., Moscow Univ. Chem. Bull. (Engl. Transl.), 2014, vol. 69, no. 3, p. 117.
Balabushevich, N.G. and Larionova, N.I., J. Microencapsulation, 2009, vol. 26, no. 7, p. 571.
Balabushevich, N.G., Lebedeva, O.V., Vinogradova, O.I., and Larionova, N.I., J. Drug Delivery Sci. Technol., 2006, vol. 16, no. 4, p. 315.
Tao, X., Chen, H., Sun, X.-J., Chen, J.-F., and Roa, W.H., Int. J. Pharm., 2007, vol. 336, p. 376.
Zhao, Q., Han, B., Wang, Z., Gao, C., Peng, C., and Shen, J., Nanomedicine, 2007, vol. 3, no. 1, p. 63.
Gupta, G.K., Kansal, S., Misra, P., Dube, A., and Mishra, P.R., AAPS PharmSciTech, 2009, vol. 10, no. 4, p. 1343.
Deng, Z.J., Morton, S.W., Ben-Akiva, E., Dreaden, E.C., Shopsowitz, K.E., and Hammond, P.T., ACS Nano, 2013, vol. 7, no. 11, p. 9571.
Balabushevich, N.G. and Larionova, N.I., Biochemistry (Moscow), 2004, vol. 69, no. 7, p. 757.
Balabushevich, N.G., Pechenkin, M.A., Zorov, I.N., Shibanova, E.D., and Larionova, N.I., Biochemistry (Moscow), 2011, vol. 76, no. 3, p. 327.
Balabushevich, N.G., Pechenkin, M.A., Shibanova, E.D., Volodkin, D.V., and Mikhalchik, E.V., Macromol. Biosci., 2013, vol. 13, no. 10, p. 1379.
Pechenkin, M.A., Balabushevich, N.G., Zorov, I.N., Izumrudov, V.A., Klyachko, N.L., Kabanov, A.V., and Larionova, N.I., Pharm. Chem. J., 2013, vol. 47, no. 1, p. 62.
Balabushevich, N.G., Borzenkova, N.V., Izumrudov, V.A., Larionova, N.I., Bezborodova, O.A., Nemtsova, E.R., and Yakubovskaya, R.I., Appl. Biochem. Microbiol., 2014, vol. 50, no. 2, p. 206.
Tan, M.L., Friedhuber, A.M., Dunstan, D.E., Choong, P.F.M., and Dass, C.R., Biomaterials, 2010, vol. 31, p. 541.
Delair, T., Eur. J. Pharm. Biopharm., 2011, vol. 78, p. 10.
Sijumon Kunjachan, Swati Gupta, Anil K. Dwivedi, Anuradha Dube, and Manish, K., J. Microencapsulation, 2011, no. 4, p. 301.
Dubois, M., Gilse, A., Hamilton, S.K., Robers, P.A., and Smith, F., Anal. Chem., 1956, vol. 28, no. 3, p. 350.
Kirzhanova, E.A., Khutoryanskii, V.V., Balabushevich, N.G., Kharenko, A.V., and Demina, N.B., Razrabotka Registr. Lek. Sredstv, 2014, no. 3, p. 58.
Bansil, R. and Turner, B.S., Curr. Opin. Colloid Interface Sci., 2006, vol. 11, p. 164.
He, P., Davis, S.S., and Illum, L., Int. J. Pharm., 1998, vol. 166, p. 75.
Treatment and Management of Bladder Cancer, Lerner, S.R., Schoenberg, M.P., and Sternberg, C.N., Eds., Informa UK, 2008.
Gan, Y., Wientjes, M.G., Badalament, R.A., and Au, J.L., Clin. Cancer Res., 1996, vol. 8, p. 1275.
Ortiz, R., Au, J.L., Lu, Z., Gan, Y., and Wientjes, M.G., AAPS J., 2007, vol. 9, no. 2, p. 241.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © P.S. Averin, A.V. Lopes de Gerenyu, N.G. Balabushevich, 2016, published in Vestnik Moskovskogo Universiteta. Khimiya, 2016, No. 2, pp. 120–126.
About this article
Cite this article
Averin, P.S., Lopes de Gerenyu, A.V. & Balabushevich, N.G. Polyelectrolyte micro- and nanoparticles with doxorubicin. Moscow Univ. Chem. Bull. 71, 140–145 (2016). https://doi.org/10.3103/S0027131416020012
Received:
Published:
Issue Date:
DOI: https://doi.org/10.3103/S0027131416020012