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Neuroinflammation and Alzheimer’s disease: lessons learned from 5-lipoxygenase

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Translational Neuroscience

Abstract

Aside from the well-known amyloid beta and tau pathologies found in Alzheimer’s disease (AD), neuroinflammation is a well-established aspect described in humans and animal models of the disease. Inflammatory perturbations are evident not only in neurons, but also in non-neuronal cells and cytokines in the AD brain. Although the amyloid hypothesis implicates amyloid beta (Aβ) as the prime initiator of the AD, brain inflammation in AD has a complex relationship between Aβ and tau. Using our work with the 5-lipoxygenase protein as an example, we suggest that at least in the case of AD, there is an interdependent and not necessarily hierarchical pathological relationship between Aβ, tau and inflammation.

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Authors and Affiliations

  1. Department of Pharmacology and Center for Translational Medicine, Temple University School of Medicine, Philadelphia, PA, 19140, USA

    Yash B. Joshi & Domenico Praticò

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  1. Yash B. Joshi
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  2. Domenico Praticò
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Correspondence to Domenico Praticò.

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Joshi, Y.B., Praticò, D. Neuroinflammation and Alzheimer’s disease: lessons learned from 5-lipoxygenase. Translat.Neurosci. 5, 197–202 (2014). https://doi.org/10.2478/s13380-014-0225-7

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  • DOI: https://doi.org/10.2478/s13380-014-0225-7

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