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Increased oxidative stress status in rat serum after five minutes treadmill exercise

  • Research Article
  • Published:
Central European Journal of Medicine

Abstract

Although it is accepted that an important correlation exists between the physical exercise and the oxidative stress status, the data regarding the levels of the main oxidative stress markers after physical training have been difficult to interpret and a subject of many controversies. There are also very few studies regarding the effects of short-time exercise on the oxidative stress status modifications. Thus, in the present report we were interested in studying the modifications of some oxidative stress markers (two antioxidant enzymes-superoxide dismutase and glutathione peroxidase, a lipid peroxidation parameter — malondyaldehide, the total antioxidant status and protein carbonyl levels), from the serum of rats that were subject to one bout of five minutes exercise on a treadmill, when compared to a control sedentary group. In this way, we observed a decrease of superoxide dismutase specific activity in the rats which performed the exercises. Still, no modifications of glutathione peroxidase specific activity were found between groups. In addition, increased levels of malondyaldehide and protein carbonyls were observed in the rats subjected to exercises. In conclusion, our data provides new evidence regarding the increase of the oxidative stress status, as a result of a 5-minutes bout of treadmill exercising in rats, expressed through a decrease in the SOD specific activity and the total antioxidant status and also an increase of the lipid peroxidation and protein oxidation processes.

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Authors and Affiliations

  1. “Alexandru Ioan Cuza” University, Iasi, 700506, Romania

    Florin-Petrut Trofin, Alin Ciobica, Dumitru Cojocaru, Marin Chirazi, Cezar Honceriu & Sabina Ioana Cojocaru

  2. Center of Biomedical Research of the Romanian Academy, Iasi Branch, Iasi, Romania

    Alin Ciobica

  3. Colegiul Tehnic „Ion Creanga”, Tg. Neamt, Romania

    Laurentiu Trofin

  4. “Gr. T. Popa” University of Medicine and Pharmacy, 700115, Iasi, Romania

    Dragomir Serban, Daniel Timofte & Emil Anton

Authors
  1. Florin-Petrut Trofin
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  2. Alin Ciobica
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  3. Dumitru Cojocaru
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  4. Marin Chirazi
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  5. Cezar Honceriu
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  6. Laurentiu Trofin
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  7. Dragomir Serban
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  8. Daniel Timofte
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  9. Sabina Ioana Cojocaru
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  10. Emil Anton
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Corresponding author

Correspondence to Dragomir Serban.

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These authors equally contributed to this work (as last and coordinating author).

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Trofin, FP., Ciobica, A., Cojocaru, D. et al. Increased oxidative stress status in rat serum after five minutes treadmill exercise. cent.eur.j.med 9, 722–728 (2014). https://doi.org/10.2478/s11536-013-0329-4

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  • DOI: https://doi.org/10.2478/s11536-013-0329-4

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