Abstract
A method of embedding micro-optics into a microfluidic device was proposed and demonstrated. First, the usefulness of embedded right-angle prisms was demonstrated in microscope observation. Lateral-view microscopic observation of an aqueous dye flow in a 100-μm-sized microchannel was demonstrated. Then, the embedded right-angle prisms were utilized for multi-beam laser spectroscopy. Here, crossed-beam thermal lens detection of a liquid sample was applied to glucose detection.
Similar content being viewed by others
References
M. L. Kovarik, D. M. Ornoff, A. T. Melvin, N. C. Dobes, Y. L. Wang, A. J. Dickinson, P. C. Gach, P. K. Shah, and N. L. Allbritton, Anal. Chem., 2013, 85, 451.
P. A. Auroux, D. Iossifidis, D. R. Reyes, and A. Manz, Anal. Chem., 2002, 74, 2637.
D. R. Reyes, D. Iossifidis, P. A. Auroux, and A. Manz, Anal. Chem., 2002, 74, 2623.
S. Masuda, M. Washizu, and T. Nanba, IEEE Trans. Ind. Appl., 1989, 25, 732.
R. Mukhopadhyay, Anal. Chem., 2007, 79, 3248.
B. Kuswandi, Nuriman, J. Huskens, and W. Verboom, Anal. Chim. Acta, 2007, 601, 141.
A. D. Stroock and G. M. Whitesides, Electrophoresis, 2002, 23, 3461.
R. F. Ismagilov, J. M. K. Ng, P. J. A. Kenis, and G. M. Whitesides, Anal. Chem., 2001, 73, 5207.
K. J. Lee, K. A. Fosser, and R. G. Nuzzo, Adv. Funct. Mater., 2005, 15, 557.
J. Kim and B. K. Gale, Lab Chip, 2008, 8, 1516.
Y. Imura, E. Yoshimura, and K. Sato, Anal. Sci., 2012, 28, 197.
K. Uchiyama, W. Xu, J. Qiu, and T. Hobo, Fresenius’ J. Anal. Chem., 2001, 371, 209.
R. H. Cole, N. de Lange, Z. J. Gartner, and A. R. Abate, Lab Chip, 2015, 15, 2754.
M. L. Chabinyc, D. T. Chiu, J. C. McDonald, A. D. Stroock, J. F. Christian, A. M. Karger, and G. M. Whitesides, Anal. Chem., 2001, 73, 4491.
S. Camou, H. Fujita, and T. Fujii, Lab Chip, 2003, 3, 40.
M. Rosenauer and M. J. Vellekoop, Lab Chip, 2009, 9, 1040.
T. Kitamori, M. Tokeshi, A. Hibara, and K. Sato, Anal. Chem., 2004, 76, 52a.
M. A. Proskurnin, E. S. Ryndina, D. S. Tsar’kov, V. M. Shkinev, A. Smirnova, and A. Hibara, Anal. Sci., 2011, 27, 381.
Y. Kazama and A. Hibara, in The 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences, 2010, Transducers Research Foundation, Groningen, The Netherlands, 1262.
D. A. Nedosekin, E. I. Galanzha, E. Dervishi, A. S. Biris, and V. P. Zharov, Small, 2014, 10, 135.
P. Vermeulen, L. Cognet, and B. Lounis, J. Microsc., 2014, 254, 115.
V. S. Dudko, A. P. Smirnova, M. A. Proskurnin, A. Hibara, and T. Kitamori, Russ. J. Gen. Chem., 2012, 82, 2146.
K. Uchiyama, A. Hibara, H. Kimura, T. Sawada, and T. Kitamori, Jpn. J. Appl. Phys. 1, 2000, 39, 5316.
D. S. Burgi and N. J. Dovichi, Appl. Opt., 1987, 26, 4665.
Acknowledgments
A part of this study was supported by JSPS KAKENHI Grant Number 15H03825. Y. K. acknowledges the support from the Global Center of Excelence (GCOE) Program of Japan’s Ministry of Education, Culture, Sports, Science adn Technology and the JSPS International Training Program.
Author information
Authors and Affiliations
Electronic supplementary material
Rights and permissions
About this article
Cite this article
Kazama, Y., Hibara, A. Integrated Micro-Optics for Microfluidic Detection. ANAL. SCI. 32, 99–102 (2016). https://doi.org/10.2116/analsci.32.99
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.2116/analsci.32.99