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Assessment of Concentrations of Four Phenothiazine Antipsychotics in Serum and Whole Blood Using Different Diatomaceous Earth-based Solid-phase Columns: A Comparative Analysis

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Abstract

This study attempted to determine the phenothiazine antipsychotics concentration in serum and whole blood samples using various diatomaceous earth-based solid-phase columns and elution solvents and subsequently evaluate their efficiency. Phenothiazine antipsychotics concentrations of 5–2000 ng/mL were extracted from serum and whole blood using each column. All compounds were analyzed using liquid chromatography–tandem mass spectrometry. Phenothiazine antipsychotics extraction in serum and whole blood using diatomaceous earth-based solid-phase columns seemed to have an affinity with the elution solvent.

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Acknowledgments

This work was supported in part by the Japan Society for the Promotion of Science KAKENHI Grant No. JP17K09278.

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Authors and Affiliations

  1. Department of Emergency and Critical Care Medicine, Tokai University School of Medicine, Kanagawa, 259-1143, Japan

    Takeshi Saito, Tomoatsu Tsuji & Sadaki Inokuchi

  2. Department of Forensic Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, 734-8553, Japan

    Akira Namera

Authors
  1. Takeshi Saito
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  2. Akira Namera
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  3. Tomoatsu Tsuji
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  4. Sadaki Inokuchi
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Correspondence to Takeshi Saito.

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Saito, T., Namera, A., Tsuji, T. et al. Assessment of Concentrations of Four Phenothiazine Antipsychotics in Serum and Whole Blood Using Different Diatomaceous Earth-based Solid-phase Columns: A Comparative Analysis. ANAL. SCI. 35, 815–819 (2019). https://doi.org/10.2116/analsci.19N006

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  • DOI: https://doi.org/10.2116/analsci.19N006

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