Abstract
OBJECTIVES: To determine the Canadian age-adjusted incidence rates of lower limb amputation (LLA) by province, sex, level, and cause of amputation.
METHODS: Data on all hospital discharges associated with LLA from April 1,2006, to March 31,2012, were obtained from the Canadian Institute for Health Information’s Discharge Abstract Database. National and provincial age-adjusted rates were calculated per 100 000 individuals by sex, level, and cause of LLA using the direct method of standardization. The relative risk of LLA in people with diabetes was calculated.
RESULTS: There were a total of 44 430 LLAs performed in Canada over the study years. The number of LLAs increased from 7331 in 2006 to 7708 in 2011. Mean (SD) age was 65.7 (16.6) years, and 68.8% were males. Sixty-five percent of the LLA cases were due to diabetes. The average age-adjusted rate of LLA in Canada was 22.9 per 100000 individuals. The age-adjusted rates declined over the study years. The relative risk of diabetes-related LLAs was 28.9.
CONCLUSION: This study provided the first Canadian national and provincial age-adjusted incidence rates of LLA and a baseline for monitoring and evaluation in the future. Understanding the incidence of LLA is essential to managing preventive and rehabilitation services for this population. Although the age-adjusted LLA incidence rates have decreased, the number of new LLAs has increased. The increase in the number of LLAs has important implications for social and health care costs.
Résumé
OBJECTIFS : Déterminer les taux d’incidence des amputations de membres inférieurs (AMI) rajustés selon l’âge au Canada par province, par sexe, par niveau et par cause d’amputation.
MÉTHODE : Les données sur les sorties de l’hôpital associées aux AMI entre le 1er avril 2006 et le 31 mars 2012 proviennent de la Base de données sur les congés des patients de l’Institut canadien d’information sur la santé. Les taux nationaux et provinciaux rajustés selon l’âge ont été calculés pour 100 000 habitants par sexe, par niveau et par cause d’AMI selon la méthode de standardisation directe. Le risque relatif d’AMI chez les personnes diabétiques a aussi été calculé.
RÉSULTATS : En tout, 44 430 AMI ont été effectuées au Canada au cours de la période à l’étude. Le nombre d’AMI a augmenté, passant de 7 331 en 2006 à 7 708 en 2011. L’âge moyen (SD) des patients était de 65,7 ans (16,6), et 68,8 % étaient des hommes. Soixante-cinq p. cent des cas d’AMI étaient dus au diabète. Le taux moyen d’AMI rajusté selon l’âge au Canada était de 22,9 pour 100 000 habitants. Les taux rajustés selon l’âge ont baissé au cours des années de l’étude. Le risque relatif d’AMI liée au diabète était de 28,9.
CONCLUSION : Cette étude est la première à fournir les taux d’incidence des AMI nationaux et provinciaux rajustés selon l’âge au Canada et constitue une base de référence pour en faire le suivi et l’évaluation à l’avenir. Il est essentiel de comprendre l’incidence des AMI pour gérer les services de prévention et de réadaptation dans la population en question. Bien que les taux d’incidence des AMI rajustés selon l’âge aient diminué, le nombre de nouvelles AMI augmente. Cette augmentation a d’importantes répercussions sur les coûts des soins de santé et des services sociaux.
Similar content being viewed by others
References
Dillingham TR, Pezzin LE, Shore, AD. Reamputation, mortality, and health care costs among persons with dysvascular lower-limb amputations. Arch Phys MedRehabil 2005;86(3):480–86. PMID: 15759232. doi: 10.1016/j.apmr.2004.06.072.
Lusardi ML, Nielsen CC (Eds.). Orthotics and Prosthetics in Rehabilitation, 2nd, ed. St. Louis, MO: Saunders/Elsevier, 2007.
Moxey PW, Gogalniceanu P, Hinchliffe RJ, Loftus IM, Jones KJ, Thompson MM, et al. Lower extremity amputations — A review of global variability in incidence. DiabetMed 2011;28(10):1144–53. PMID: 21388445. doi: 10.1111/j.1464-5491.2011.03279.x.
Fortington LV, Rommers GM, Postema K, van Netten JJ, Geertzen JH, Dijkstra, PU. Lower limb amputation in Northern Netherlands: Unchanged incidence from 1991–1992 to 2003–2004. Prosthet Orthot Int 2013;37(4):305–10. PMID: 23327835. doi: 10.1177/0309364612469385.
Buckley CM, O’Farrell A, Canavan RJ, Lynch AD, De La Harpe DV, Bradley CP, et al. Trends in the incidence of lower extremity amputations in people with and without diabetes over a five-year period in the Republic of Ireland. PLoS ONE 2012;7(7):e41492. PMID: 22859991. doi: 10.1371/journal.pone.0041492.
Dillingham TR, Pezzin LE, Mackenzie, EJ. Limb amputation and limb deficiency: Epidemiology and recent trends in the United States. South Med J 2002;95(8):875–83. PMID: 12190225.
Belatti DA, Phisitkul P. Declines in lower extremity amputation in the US Medicare population, 2000–2010. Foot Ankle Int 2013;34(7):923–31. PMID: 23386749. doi: 10.1177/1071100713475357.
Dawes D, Iqbal S, Steinmetz OK, Mayo N. The evolution of amputation in the province of Quebec. Can J Diabetes 2010;34(1):58–66. doi: 10.1016/S1499- 2671(10)41011-4.
Varma P, Stineman MG, Dillingham, TR. Epidemiology of limb loss. Phys Med Rehabil Clin NAm 2014;25(1):1–8. PMID: 24287235. doi: 10.1016/j.pmr.2013.09.001.
Lawee D, Csima A. Diabetes-related lower extremity amputations in Ontario: 1987-88 experience. Can JPublicHealth 1992;83(4):298–302. PMID: 1423112.
Statistics Canada. Canadian Community Health Survey, 2009. Available at: http://www.statcan.gc.ca/daily-quotidien/100615/dq100615b-eng.htm (Accessed December 23, 2016).
Statistics Canada. Diabetes, by Sex, Provinces and Territories, 2013. Available at: http://www.statcan.gc.ca/tables-tableaux/sum-som/l01/cst01/health54a-eng.htm (Accessed December 23, 2016).
Hoem, JM. Statistical analysis of a multiplicative model and its application to the standardization of vital rates: A review. Inter Stat Rev 1987;55(2):119–52. doi: 10.2307/1403190.
Inskip H, Beral V, Fraser P, Haskey J. Methods for age-adjustment of rates. Stat Med 1983;2:455–66. PMID: 6672943. doi: 10.1002/sim.4780020404.
Kayssi A, de Mestral C, Forbes TL, Roche-Nagle G. A Canadian population-based description of the indications for lower-extremity amputations and outcomes. Can J Surg 2016;59:99–106. PMID: 27007090. doi: 10.1503/cjs.013115.
Canadian Institute for Health Information. International Statistical Classification of Diseases and Related Health Problems, 10th Revision, 2012. Available at: http://www.cihi.ca/CIHI-extportal/pdf/internet/ICD_VOLUME_ONE_2012_EN (Accessed December 23, 2016).
Canadian Institute for Health Information. Canadian Classification of Health Interventions, 2012. Available at: http://www.cihi.ca/CIHI-ext-portal/pdf/internet/CCI_VOLUME_THREE_2012_EN (Accessed December 23, 2016).
Statistics Canada. Estimates of Population, by Age Group and Sex for July 1, Canada, Provinces and Territories, 2011. Available at: http://www5.statcan.gc.ca/cansim/a26?lang=eng&id=510001 ai](Accessed December 23, 2016).
Lee WC, Liaw, YP. Optimal weighting systems for direct age-adjustment of vital rates. Stat Med 1999;18(19):2645–54. PMID: 10495462. doi: 10.1002/(SICI)1097-0258(19991015)18:19<2645::AID-SIM184>3.0.CO;2-Q.
Cowger, CD. Statistical significance tests: Scientific ritualism or scientific method? Soc Serv Rev 1984;58(3):358–372. doi: 10.1086/644212.
Kvitkina T, Narres M, Claessen H, Droste S, Morbach S, Kuss O, et al. Incidence of lower extremity amputation in the diabetic compared to the non-diabetic population: A systematic review protocol. Syst Rev 2015;4:74. PMID: 26001384. doi: 10.1186/s13643-015-0064-9.
Vamos EP, Bottle A, Edmonds ME, Valabhji J, Majeed A, Millett C. Changes in the incidence of lower extremity amputations in individuals with and without diabetes in England between 2004 and 2008. Diabetes Care 2010;33(12):2592–97. PMID: 20833865. doi: 10.2337/dc10-0989.
Fletcher DD, Andrews KL, Hallett JW Jr, Butters MA, Rowland CM, Jacobsen, SJ. Trends in rehabilitation after amputation for geriatric patients with vascular disease: Implications for future health resource allocation. Arch Phys MedRehabil 2002;83(10):1389–93. PMID: 12370874. doi: 10.1053/apmr.2002.34605.
Carmona GA, Hoffmeyer P, Herrmann FR, Vaucher J, Tschopp O, Lacraz A, et al. Major lower limb amputations in the elderly observed over ten years: The role of diabetes and peripheral arterial disease. Diabetes Metab 2005;31(5): 449–54. PMID: 16357788. doi: 10.1016/S1262-3636(07)70215-X.
Fosse S. Incidence and characteristics of lower limb amputations in people with diabetes. Diabetic Med 2009;26(4);391–96. PMID: 19388969. doi: 10. 1111/j.1464-5491.2009.02698.x.
Canadian Diabetes Association Clinical Practice Guidelines Expert Committee. Canadian Diabetes Association 2008 clinical practice guidelines for the prevention and management of diabetes in Canada. Can J Diabetes 2008;32:S1–201.
Canadian Institute for Health Information. Diabetes Care Gaps and Disparities in Canada. Ottawa, ON: Canadian Institute for Health Information, 2009. Available at: https://secure.cihi.ca/free_products/Diabetes_care_gaps_disparities_aib_e.pdf (Accessed December 23, 2016).
Sanmartin C, Gilmore J. Diabetes: Prevalence and care practices. Health Rep 2008;19(3):59–63. PMID: 18847146.
Dormandy J, Heeck L, Vig S. Major amputations: Clinical patterns and predictors. Semin VascSurg 1999;12(2):154–61. PMID: 10777243.
Stewart CPU, Condie, ME. Amputee rehabilitation. Rev Clin Gerontol 1996;6(3):273–83. doi: 10.1017/S0959259800004779.
Dillon MP, Kohler F, Peeva V. Incidence of lower limb amputation in Australian hospitals from 2000 to 2010. Prosthet Orthot Int 2014;38:122–32. PMID: 23798042. doi: 10.1177/0309364613490441.
Gamba MA, Gotlieb SL, Bergamaschi DP, Vianna, LA. Lower extremity amputations in diabetic patients: A case-control study. Rev Saude Publica 2004;38:399–404. PMID: 15243670. doi: 10.1590/S0034-89102004000300010.
Johannesson A, Larsson GU, Ramstrand N, Turkiewicz A, Wiréhn AB, Atroshi I. Incidence of lower-limb amputation in the diabetic and nondiabetic general population: A 10-year population-based cohort study of initial unilateral and contralateral amputations and reamputations. Diabetes Care 2009;32:275–80. PMID: 19001192. doi: 10.2337/dc08-1639.
Author information
Authors and Affiliations
Corresponding author
Additional information
Acknowledgements: We acknowledge the Canadian Institute for Health Information for providing the data for this study and our staff at GF Strong Rehabilitation Research Program for helping with the study.
Funding: This study was funded by Amputee Coalition of Canada and the University of Alberta’s Faculty of Medicine & Dentistry-Franklin Fund. Vanier Canada graduate scholarships provided salary for Bita Imam. Michael Smith Foundation provided salary for Janice Eng.
Conflict of Interest: None to declare.
Rights and permissions
About this article
Cite this article
Imam, B., Miller, W.C., Finlayson, H.C. et al. Incidence of lower limb amputation in Canada. Can J Public Health 108, 374–380 (2017). https://doi.org/10.17269/CJPH.108.6093
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.17269/CJPH.108.6093