Abstract
Background
Malignant melanoma cases arising in tattoos have been increasingly described, however, there is no clear relationship between this practice and the development of cutaneous malignancies.
Objectives
We report a newcase of melanoma in a dark-blue tattoo and we reviewall cases of melanoma reported in the medical literature from 1938 to date.
Materials & methods
Pubmed and Google Scholar were searched using the terms “melanoma tattoo”, “tattoo skin tumour” and “ink melanoma”.
Results
In most cases, the melanoma occurred on dark blue (10/30), black (8/30), or blue ink (3/30). The Breslow thickness at diagnosis was ≤1 mm in 13/30, 1-2 mm in 3/30, 2-4 mm in 2/30, >4 mm in 5/30, and Clark II in 2/30 (not available in 5/30).
Conclusions
Both the incidence of melanoma and the number of tattoos have been increasing in recent years, but a possible carcinogenic effect of tattoos remains unproven. The spread of this decorative custom will make observation of melanoma in tattoos more frequent in dermatological practice, therefore these cases should be reported in national skin cancer registries.
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References
Kluger N, Koljonen V. Tattoos, inks, and cancer. Lancet Oncol 2012; 13: e161–8.
Laumann AE, Derick AJ. Tattoos and body piercings in the United States: a national data set. J Am Acad Dermatol 2006; 55: 413–21.
Klügl I, Hiller KA, Landthaler M, Bäumler W. Incidence of health problems associated with tattooed skin: a nation-wide survey in German-speaking countries. Dermatology 2010; 221: 43–50.
Patrick K, Smith AM, Simpson JM, et al. Who gets tattoos? Demographic and behavioral correlates of ever being tattooed in a representative sample of men and women. Ann Epidemiol 2012; 22: 51–6.
Heiwood W, Wenzel SM, Rittmann I, Bäumler W. Adverse reactions after tattooing: review of the literature and comparison to results of a survey. Dermatology 2013; 226: 138–47.
Sharlit H. Melanoma caused by indelible pencil. Arch Dermatol 1938; 37: 301–6.
Allen AC. The Skin. St Louis: CV Mosby Co, 1954.
Kirsch N. Malignant melanoma developing in a tattoo. Arch Dermatol 1969; 99: 596–8.
Kirsch N. Malignant melanoma developing in a tattoo. Int J Dermatol 1972; 11: 16–20.
Wolfort FC, Hoopes JE, Filtze HS, Cochran TC. Superficial melanoma in a tattoo. Br J Plast Surg 1974; 27: 303–4.
Bartal AH, Cohen Y, Robinson E. Malignant melanoma arising at tattoo sites used for radiotherapy field marking. Br J Radiol 1980; 3: 913–4.
Lee YT, Craig JR. Melanoma in a tattoo of the breast. J Surg Oncol 1984; 25: 100–1.
Kircik L, Armus S, van den Broek H. Malignant melanoma in a tattoo. Int J Dermatol 1993; 32: 297–8.
Soroush V, Gurevitch AW, Peng SK. Malignant melanoma in a tattoo: case report and review of the literature. Cutis 1997; 59: 111–2.
Khan IU, Moiemen NS, Firth J, Frame JD. Malignant melanoma disguised by a tattoo. Br J Plast Surg 1999; 52: 598.
Stinco G, De Francesco V, Frattasio A, Quinkenstein E, Patrone P. Malignant melanoma in a tattoo. Dermatology 2003; 206: 345–6.
Paradisi A, Capizzi R, De Simone C, Fossati B, Proietti I, Amerio PL. Malignant melanoma in a tattoo: case report and review of the literature. Melanoma Res 2006; 16: 375–6.
Shariff Z, Tehrani H, Jagadeesan J, Hardwicke J. Artwork: to be studied. Dermatol Online J 2006; 12: 21.
Singh RS, Hafeez Diwan A, Prieto VG. Potential diagnostic pitfalls in melanoma arising in a cutaneous tattoo. Histopathology 2007; 51: 283–5.
Kluger N, Phan A, Debarbieux S, Balme B, Thomas L. Skin cancers arising in tattoos: coincidental or not? Dermatology 2008; 217: 219–21.
Jaigirdar AA, Yeh MW, Sharifi E, Browne LW, Leong SP. Coexisting tattoo pigment and metastatic melanoma in the same sentinel lymph node. J Cutan Med Surg 2009; 13: 321–5.
Varga E, Korom I, Varga J, Kohán J, Kemény L, Oláh J. Melanoma and melanocytic nevi in decorative tattoos: three case reports. J Cutan Pathol 2011; 38: 994–8.
Nolan KA, Kling M, Birge M, Kling A, Fishman S, Phelps R. Melanoma arising in a tattoo: case report and review of the literature. Cutis 2013; 92: 227–30.
Körner R, Pföhler C, Vogt T, Müller CS. Histopathology of body art revisited -analysis and discussion of 19 cases. J Dtsch Dermatol Ges 2013; 11: 1073–80.
Pohl L, Kaiser K, Raulin C. Pitfalls and recommendations in cases of laser removal of decorative tattoos with pigmented lesions: case report and review of the literature. JAMA Dermatol 2013; 149: 1087–9.
Kluger N, Koskenmies S, Jeskanen L, Övermark M, Saksela O. Melanoma on tattoos: two Finnish cases. Acta Derm Venereol 2014; 94: 325–6.
Kluger N, Saarinen K. Melanoma on a tattoo. Presse Med 2015; 44: 473–5.
Anthony EP, Godbolt A, Tang F, McMeniman EK. Malignant melanoma disguised in a tattoo. Australas J Dermatol 2015; 56: 232–3.
Joyce CW, Duff G, McKenna D, Regan PJ. Malignant melanoma arising in red tattoo ink. Arch Plast Surg 2015; 42: 475–7.
Caccavale S, Moscarella E, De Fata Salvatores G, Piccolo V, Russo T, Argenziano G. When a melanoma is uncovered by a tattoo. Int J Dermatol 2016; 55: 79–80.
Tchernev G, Chokoeva AA. Melanoma in a Chinese dragon tattoo. Lancet 2015; pii: S0140-6736(15)01038-7.
Deinlein T, Arzberger E, Scarfi F, Fink Puches R, Hofmann-Wellenhof R, Zalaudek I. A dangerous fruit of Belladonna. J Am Acad Dermatol 2016; 75: e93–4.
Bero SM, Busam KJ, Brady MS. Cutaneous melanoma arising in a burn scar: two recent cases and a review of the literature. Melanoma Res 2006; 16: 71–6.
Sheff JS, Pane TA. Spindle cell melanoma arising from decadesold burn scar. Plast Reconstr Surg 2009; 124: e274–5.
Kaskel P, Kind P, Sander S, Peter RU, Krähn G. Trauma and melanoma formation: a true association? Br J Dermatol 2000; 143: 749–53.
Zhang N, Wang L, Zhu GN, et al. The association between trauma and melanoma in the Chinese population: a retrospective study. J Eur Acad Dermatol Venereol 2014; 28: 597–603.
Baumler W, Vasold R, Lundsgaard J, Talberg HJ. Chemical used in tattooing and permanent make up products. In: Workshop on Technical/ Scientific and Regulatory Issues on the Safety of Tattoos, Body Piercing and of Related Practices. Papameletiou D, Schwela D, Zenie A. European Commission, 2003: 21–37.
Engel E, Vasold R, Baumler W. Tatowierungspigmente im Fokus der Forschung. Nachrichten aus der Chemie 2007; 55: 847–51.
Kluger N, Plantier F, Moguelet P, Fraitag S. Tattoos: natural history and histopathology of cutaneous reactions. Ann Dermatol Venereol 2011; 138: 146–54.
Hannah H, Falder S, Steele PR, Dhital SK. Tattoo pigment masquerading as secondary malignant melanoma. Br J Plast Surg 2000; 53: 359.
Scevola S, Gault DT. Black nodes: no melanoma. Plast Reconstr Surg 2001; 108: 1458e9.
Kluger N, Cohen-Valensi R, Nezri M. Black lymph nodes-and a colourful skin. Lancet 2008; 371: 1214.
Balasubramanian I, Burke JP, Condon E. Painful, pigmented lymphadenopathy secondary to decorative tattooing. Am J Emerg Med 2013; 31: 1001.e1-2.
Bordea C, Latifaj B, Jaffe W. Delayed presentation of tattoo lymphadenopathy mimicking malignant melanoma lymphadenopathy. J Plast Reconstr Aesthetic Surg 2009; 62: e283–5.
Jack CM, Adwani A, Krishnan H. Tattoo pigment in an axillary lymph node simulating metastatic malignant melanoma. Int Semin Surg Oncol 2005; 2: 28.
Anderson LL, Cardone JS, McCollough ML, Grabski WJ. Tattoo pigment mimicking metastatic malignant melanoma. Dermatol Surg 1996; 22: 92–4.
Kluger N, Koljonen V. The surgeon, the tattoo and the black lymph node. J Plast Reconstr Aesthet Surg 2013; 66: 561–2.
Yang AS, Creagh TA. Black sentinel lymph node and “scary stickers”. J Plast Reconstr Aesthet Surg 2013; 66: 558–60.
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Ricci, F., Paradisi, A., Maier, S.A. et al. Melanoma and tattoos: a case report and review of the literature. Eur J Dermatol 28, 50–55 (2018). https://doi.org/10.1684/ejd.2017.3184
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DOI: https://doi.org/10.1684/ejd.2017.3184