Abstract
Food allergy (FA) is a global health problem that affects a large population, and thus effective treatment is highly desirable. Oral immunotherapy (OIT) has been showing reasonable efficacy and favorable safety in most FA subjects. Dependable biomarkers are needed for treatment assessment and outcome prediction during OIT. Several immunological indicators have been used as biomarkers in OIT, such as skin prick tests, basophil and mast cell reactivity, T cell and B cell responses, allergen-specific antibody levels, and cytokines. Other novel indicators also could be potential biomarkers. In this review, we discuss and assess the application of various immunological indicators as biomarkers for OIT.
概要
食物过敏(food allergy,FA)是影响大量人口的全球健康问题之一,因此非常需要有效的治疗。口服免疫治疗(oral immunotherapy,OIT)在大多数FA受试者中显示出良好的疗效和安全性。OIT期间需要可靠的生物标志物进行治疗评估和结果预测。多种免疫学指标已被用作OIT的生物标志物,例如皮肤点刺试验、嗜碱性粒细胞和肥大细胞反应性、T细胞和B细胞应答反应、过敏原特异性抗体水平和细胞因子等。其他新的指标也可作为潜在的生物标志物。本文讨论并评估了各种免疫相关指标作为OIT生物标志物的应用。
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Acknowledgments
This work was supported by the Talent Training Project of Northwest Women’s and Children’s Hospital (No. 2018LQ01), the National Natural Science Foundation of China (No. 82070858), and the Natural Science Foundation of Shaanxi Province (Nos. 2020JQ-941 and 2021JQ-911), China. We thank Dr. Ning JING (Xi’an Sanmin Community Health Service Station) for language polishing of the original version of this manuscript, and Jingwen ZHU (Xi’an Gaoxin No. 1 Primary School) for color design of Fig. 1. In addition, Dr. Haitao ZHU wants to thank, in particular, the patience, generous heart and love from Dr. Ning JING over the past 12 years. Haitao ZHU (tarn1000) will always cherish you.
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Haitao ZHU conceived the central idea and completed the manuscript. Kaifa TANG and Guoqiang CHEN contributed to manuscript review. Zhongwei LIU finalized the manuscript. All authors have read and approved the final manuscript.
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Haitao ZHU, Kaifa TANG, Guoqiang CHEN, and Zhongwei LIU declare that they have no conflict of interest.
This review does not contain any studies with human or animal subjects performed by any of the authors.
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Tables S1 and S2; Figs. S1–S3
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Zhu, H., Tang, K., Chen, G. et al. Biomarkers in oral immunotherapy. J. Zhejiang Univ. Sci. B 23, 705–731 (2022). https://doi.org/10.1631/jzus.B2200047
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DOI: https://doi.org/10.1631/jzus.B2200047