Abstract
The Coronavirus disease 2019 (COVID-19) is an emerging infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Within a matter of months, this highly contagious novel virus has led to a global outbreak and is still spreading rapidly across continents. In patients with COVID-19, underlying chronic diseases and comorbidities are associated with dismal treatment outcomes. Owing to their immunosuppressive status, patients with hematological malignancies (HMs) are at an increased risk of infection and have a worse prognosis than patients without HMs. Accordingly, intensive attention should be paid to this cohort. In this review, we summarize and analyze specific clinical manifestations for patients with coexisting COVID-19 and HMs. Furthermore, we briefly describe customized management strategies and interventions for this susceptible cohort. This review is intended to guide clinical practice.
概要
新型冠状病毒肺炎 (COVID-19) 是一种由严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 引起的新型传染病. SARS-CoV-2 具有极强的传染性, 因此在引发流行病后又使其迅速升级为全球大流行, 至今仍在部分国家迅速传播. 在 COVID-19 的感染者中, 存在肿瘤等慢性病或伴有相关合并症的患者预后往往较差. 同时, 由于恶性血液肿瘤患者长期处于免疫抑制状态, 往往感染风险更高且预后更差, 所以十分值得我们关注. 这篇综述归纳并分析了恶性血液肿瘤患者合并 COVID-19 后的临床表现. 此外, 归纳了疫情期间恶性肿瘤的管理策略和感染后的综合干预措施, 旨在为临床提供指导.
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He HUANG, Arnon NAGLER, and Yong-xian HU took the lead in writing the manuscript. Lin-qin WANG and Elaine TAN SU YIN wrote and edited the manuscript. Guo-qing WEI participated in shaping the tables and figures. All authors have read and approved the final manuscript and, therefore, have full access to all the data in the study and take responsibility for the integrity and security of the data.
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He HUANG, Arnon NAGLER, Yong-xian HU, Lin-qin WANG, Elaine TAN SU YIN, and Guo-qing WEI declare that they have no conflict of interest.
This article does not contain any studies with human or animal subjects performed by any of the authors.
Project supported by the National Natural Science Foundation of China (Nos. 81770201 and 81730008)
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Wang, Lq., Tan Su Yin, E., Wei, Gq. et al. Weathering the storm: COVID-19 infection in patients with hematological malignancies. J. Zhejiang Univ. Sci. B 21, 921–939 (2020). https://doi.org/10.1631/jzus.B2000423
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DOI: https://doi.org/10.1631/jzus.B2000423
Keywords
- Coronavirus disease 2019 (COVID-19)
- Hematological malignancies
- Immunosuppressive status
- Management strategies
- Treatment regimen