Abstract
It is commonly accepted that females and males differ in their experience of pain. Gender differences have been found in the prevalence and severity of pain in both clinical and animal studies. Sex-related hormones are found to be involved in pain transmission and have critical effects on visceral pain sensitivity. Studies have pointed out the idea that serum estrogen is closely related to visceral nociceptive sensitivity. This review aims to summarize the literature relating to the role of estrogen in modulating visceral pain with emphasis on deciphering the potential central and peripheral mechanisms.
概 要
女性和男性的疼痛感受不同, 疼痛的患病率和严 重程度也存在性别差异, 这在临床研究和动物实 验中均得到证实。 性激素参与疼痛传播并调节内脏 疼痛敏感性。 有研究发现血清雌激素水平与内脏疼 痛敏感性密切相关。 本综述旨在总结雌激素在调 节内脏痛中的作用及其相关的中枢和外周机制。
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We sincerely thank Dr. Li-na YU (School of Medicine, Zhejiang University, Hangzhou, China) for her guidance.
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Project supported by the National Natural Science Foundation of China (No. 81471126)
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Sun, Lh., Zhang, Wx., Xu, Q. et al. Estrogen modulation of visceral pain. J. Zhejiang Univ. Sci. B 20, 628–636 (2019). https://doi.org/10.1631/jzus.B1800582
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DOI: https://doi.org/10.1631/jzus.B1800582