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Heterosynaptic plasticity in memristive and memcapacitive lipid bilayers: A snapshot review

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Abstract

Synaptic plasticity refers to activity-dependent synaptic strengthening or weakening between neurons. It is usually associated with homosynaptic plasticity, which refers to a synaptic junction controlled by interactions between specific neurons. Heterosynaptic plasticity, on the other hand, lacks this specificity. It involves much larger populations of synapses and neurons and can be associated with changes in synaptic strength due to nonlocal alterations in the ambient electrochemical environment. This paper presents specific examples demonstrating how variations in the ambient electrochemical environment of lipid membranes can impact the nonlinear dynamical behaviors of memristive and memcapacitive systems in droplet interface bilayers (DIBs). Examples include the use of pH as a modulatory factor that alters the voltage-dependent memristive behavior of alamethicin ion channels in DIB lipid bilayers, and the discovery of long-term potentiation (LTP) in a lipid bilayer-only system after application of electrical stimulation protocols.

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Fig. 1
Fig. 2

Copyright 2018 American Chemical Society

Fig. 3

Adapted from MRS Bulletin 48, 13–21 (2023)

Fig. 4

Adapted from Ref. 35, Evidence for long-term potentiation in phospholipid membranes © 2022 by Scott et al. Licensed under CC BY 4.0. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

Fig. 5

Copyright 2023 American Chemical Society

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Data available from authors upon request.

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Acknowledgments

J.K. and C.P.C. are supported through the Scientific User Facilities Division of the Department of Energy (DOE) Office of Science, sponsored by the Basic Energy Science (BES) Program, DOE Office of Science, under Contract No. DE-AC05-00OR22725. D.B. is supported through the National Science Foundation, Division of Molecular and Cellular Biosciences (MCB), under contract No. 2219289. Manuscript preparation was performed at the Center for Nanophase Materials Sciences, a US DOE Office of Science User Facility.

Funding

This study is supported by the Basic Energy Sciences, DE-AC05-00OR22725, to C. Patrick Collier.

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Authors and Affiliations

  1. Department of Physics and Astronomy, The University of Tennessee, Knoxville, TN, 37996, USA

    Dima Bolmatov & John Katsaras

  2. Neutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, TN, 37831, USA

    John Katsaras

  3. Shull Wollan Center, Oak Ridge National Laboratory, Oak Ridge, TN, 37831, USA

    John Katsaras

  4. Center for Nanophase Materials Sciences, Oak Ridge National Laboratory, Oak Ridge, TN, 37831, USA

    C. Patrick Collier

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CPC wrote the manuscript. All authors edited and proofread the manuscript.

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Bolmatov, D., Katsaras, J. & Patrick Collier, C. Heterosynaptic plasticity in memristive and memcapacitive lipid bilayers: A snapshot review. MRS Advances (2024). https://doi.org/10.1557/s43580-024-00800-9

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