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Integrated hydrogel sensor-actuator for glucose sensitivity and drug elution

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Abstract

Insulin therapy has proven its effectiveness in the treatment of diabetes, but there are still several limitations, including insulin pump failure, infusion set blockage, infusion site problems, insulin stability issues, and user error, among others. In this study, we examine the fabrication of a layered hydrogel system that combines a microfluidic device with both sensing and drug delivery mechanisms. This allows for the continuous monitoring of the glucose concentration and delivers a concentration of drug that is proportional to the concentration of analyte detected in a solution. We developed a 3D-printed glucose sensitive hydrogel system where microfluidic channels would swell and de-swell in the presence of glucose. Here, we report early stage findings on hydrogel-based microfluidics and the resulting drug release kinetics of the hydrogel system.

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Authors and Affiliations

  1. Department of Materials Science and Engineering, University of Utah, Salt Lake City, USA

    Ashwin Velraj & Jeffrey Bates

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  1. Ashwin Velraj
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  2. Jeffrey Bates
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Correspondence to Jeffrey Bates.

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The authors declare that they have no conflicts of interest with the work reported in this paper.

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The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Velraj, A., Bates, J. Integrated hydrogel sensor-actuator for glucose sensitivity and drug elution. MRS Advances 7, 663–667 (2022). https://doi.org/10.1557/s43580-022-00331-1

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