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Evaluating the effect of liposomes containing vitamin E on bone metabolism

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Abstract

To prevent causing pain during movement of the skeleton system, modern drug delivery systems use carriers to protect the drug, deliver it to the target site, and increase its efficiency. Liposomal encapsulation technology is one of the most promising carriers due to its biocompatibility, natural components, and cell membrane-like structure. In this study, liposomes containing vitamin E were used to increase osteoblast cells’ metabolism. Liposomes were prepared by hydrating a lipid film and loaded using a passive loading technique. DLS and zeta potential tests showed good stability and optimal size distribution. The cell culture results showed non-toxicity and improved bone cell growth. Alkaline phosphatase activity increased in the samples containing vitamin E. Samples were prepared in three DOPE: CHEMS ratios and sonication times. The best result was from the sample with a 4:1 ratio and 20-min sonication time, which showed the maximum vitamin E loading capacity.

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Authors and Affiliations

  1. Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran

    Babak Akbari & Narges Shomalizadeh

  2. Department of Material Engineering, Shahreza Branch, Islamic Azad University, Shahreza, Isfahan, Iran

    Shabnam Shahi

Authors
  1. Babak Akbari
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  2. Narges Shomalizadeh
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  3. Shabnam Shahi
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Contributions

BA: Guidance and supervision of research, editing the manuscript. NS: Doing the research. SS: Writing the manuscript.

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Correspondence to Babak Akbari.

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Akbari, B., Shomalizadeh, N. & Shahi, S. Evaluating the effect of liposomes containing vitamin E on bone metabolism. Journal of Materials Research (2024). https://doi.org/10.1557/s43578-024-01320-w

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