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Preparation and characterization of magnetic chitosan hydroxyapatite nanoparticles for protein drug delivery and antibacterial activity

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Abstract

A novel magnetic chitosan hydroxyapatite (MCHAp) nanoparticle as a protein drug carrier was synthesized through an improved hydrothermal method. The chemical composition, microstructure, magnetic properties, and porous characteristics were investigated by X-ray diffraction, scanning electron microscopy and vibrating sample magnetometer. The characterization results indicated that Fe3O4 magnetic nanoparticles and chitosan were successfully incorporated into hydroxyapatite, which endowed the as-prepared MCHAp nanoparticle with a porous structure and excellent magnetic property. The protein drug adsorption and release behavior of the MCHAp nanoparticles were investigated with lysozyme (LYS) as a model protein drug. The MCHAp nanoparticles showed high LYS adsorption capacity (649.75 mg/g) and sustained drug release properties. In addition, magnetic chitosan hydroxyapatite nanoparticles also exhibited good bacterial inhibition performance. The MCHAp nanoparticle was expected to be a promising drug carrier for the biomedical field though more detailed protein kinetics and preclinical studies were necessary to verify these observations.

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The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (21473126) and the National Key R&D Program of China (2017YFB0304300 & 2017YFB0304303).

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Authors and Affiliations

  1. Hubei Key Laboratory of Coal Conversion and New Carbon Material, School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan, 430081, China

    Xin Li, Danlin Zeng, Lianlian Chen, Ping Ke, Yongsheng Tian & Guanghui Wang

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  1. Xin Li
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  2. Danlin Zeng
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  3. Lianlian Chen
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Correspondence to Danlin Zeng.

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Li, X., Zeng, D., Chen, L. et al. Preparation and characterization of magnetic chitosan hydroxyapatite nanoparticles for protein drug delivery and antibacterial activity. Journal of Materials Research 36, 4307–4316 (2021). https://doi.org/10.1557/s43578-021-00424-x

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