Skip to main content
SpringerLink
Log in

Shifting identities of metal oxide nanoparticles: Focus on inflammation

  • Biological Interactions of Oxide Nanoparticles: The Good and The Evil
  • Published:
MRS Bulletin Aims and scope Submit manuscript

Abstract

Metal and metal oxide nanoparticles are an important class of materials with numerous applications. Understanding how such nanoparticles interact with living systems is of considerable relevance both from a toxicological and biomedical perspective. The physicochemical features of nanoparticles are sometimes referred to as the synthetic identity, while the acquired properties of nanoparticles in a biological milieu resulting from the adsorption of biomolecules on the surface of the particles can be considered the biological identity. In this article, we explore the dynamic changes in the identity of nanoparticles resulting either from acquisition of a so-called bio-corona or through the process of biotransformation and how this impacts cellular recognition of nanoparticles and toxicological outcomes, with an emphasis on inflammation—an orchestrated host response against harmful stimuli, including pathogens as well as particles.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1
Figure 2

Similar content being viewed by others

References

  1. M. Auffan, J. Rose, J.Y. Bottero, G.V. Lowry, J.P. Jolivet, M.R. Wiesner, Nat. Nanotechnol. 4 (10), 634 (2009).

    Google Scholar 

  2. E.A. Bleeker, W.H. de Jong, R.E. Geertsma, M. Groenewold, E.H. Heugens, M. Koers-Jacquemijns, D. van de Meent, J.R. Popma, A.G. Rietveld, S.W. Wijnhoven, F.R. Cassee, A.G. Oomen, Regul. Toxicol. Pharmacol. 65 (1), 119 (2013).

    Google Scholar 

  3. N. Feliu, B. Fadeel, Nanoscale 2 (12), 2514 (2010).

    Google Scholar 

  4. M.I. Setyawati, C.Y. Tay, S.L. Chia, S.L. Goh, W. Fang, M.J. Neo, H.C. Chong, S.M. Tan, S.C. Loo, K.W. Ng, J.P. Xie, C.N. Ong, N.S. Tan, D.T. Leong, Nat. Commun. 4. 1673 (2013).

  5. M. Geiser, W.G. Kreyling, Part. Fibre Toxicol. 7, 2 (2010).

    Google Scholar 

  6. W.G. Kreyling, M. Semmler-Behnke, S. Takenaka, W. Möller, Acc. Chem. Res. 46 (3), 714 (2013).

    Google Scholar 

  7. K. Bhattacharya, F.T. Andón, R. El-Sayed, B. Fadeel, Adv. Drug Deliv. Rev. 65 (15), 2087 (2013).

    Google Scholar 

  8. R. Medzhitov, Nature 454, 428 (2008).

    Google Scholar 

  9. B. Fadeel, N. Feliu, C. Vogt, A.M. Abdelmonem, W.J. Parak, Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. 5, 111 (2013).

    Google Scholar 

  10. D. Walczyk, F.B. Bombelli, M.P. Monopoli, I. Lynch, K.A. Dawson, J. Am. Chem. Soc. 132, 5761 (2010).

    Google Scholar 

  11. M.P. Monopoli, C. Åberg, A. Salvati, K.A. Dawson, Nat. Nanotechnol. 7, 779 (2012).

    Google Scholar 

  12. M. Lundqvist, J. Stigler, T. Cedervall, T. Berggård, M.B. Flanagan, I. Lynch, G. Elia, K. Dawson, ACS Nano 5, 7503 (2011).

    Google Scholar 

  13. F. Bertoli, G.L. Davies, M.P. Monopoli, M. Moloney, Y.K. Gunko, A. Salvati, K.A. Dawson, Small 10 (16), 3307 (2014).

    Google Scholar 

  14. A. Albanese, C.D. Walkey, J.B. Olsen, H. Guo, A. Emili, W.C. Chan, ACS Nano 8, 5515 (2014).

    Google Scholar 

  15. O. Lunov, T. Syrovets, C. Loos, J. Beil, M. Delacher, K. Tron, G.U. Nienhaus, A. Musyanovych, V. Mailänder, K. Landfester, T. Simmet, ACS Nano 5 (3), 1657 (2011).

    Google Scholar 

  16. A. Lesniak, F. Fenaroli, M.P. Monopoli, C. Åberg, K.A. Dawson, A. Salvati, ACS Nano 6, 5845 (2012).

    Google Scholar 

  17. A.A. Kapralov, W.H. Feng, A.A. Amoscato, N. Yanamala, K. Balasubramanian, D.E. Winnica, E.R. Kisin, G.P. Kotchey, P. Gou, L.J. Sparvero, P. Ray, R.K. Mallampalli, J. Klein-Seetharaman, B. Fadeel, A. Star, A.A. Shvedova, V.E. Kagan, ACS Nano 6, 4147 (2012).

    Google Scholar 

  18. M.S. Ehrenberg, A.E. Friedman, J.N. Finkelstein, G. Oberdörster, J.L. McGrath, Biomaterials 30, 603 (2009).

    Google Scholar 

  19. G. Caracciolo, F. Cardarelli, D. Pozzi, F. Salomone, G. Maccari, G. Bardi, A.L. Capriotti, C. Cavaliere, M. Papi, A. Laganà, ACS Appl. Mater. Interfaces 5, 13171 (2013).

    Google Scholar 

  20. C.D. Walkey, J.B. Olsen, F. Song, R. Liu, H. Guo, D.W. Olsen, Y. Cohen, A. Emili, W.C. Chan, ACS Nano 8 (3), 2439 (2014).

    Google Scholar 

  21. D. Dutta, S.K. Sundaram, J.G. Teeguarden, B.J. Riley, L.S. Fifield, J.M. Jacobs, S.R. Addleman, G.A. Kaysen, B.M. Moudgil, T.J. Weber, Toxicol. Sci. 100 (1), 303 (2007).

    Google Scholar 

  22. S. Tenzer, D. Docter, J. Kuharev, A. Musyanovych, V. Fetz, R. Hecht, F. Schlenk, D. Fischer, K. Kiouptsi, C. Reinhardt, K. Landfester, H. Schild, M. Maskos, S.K. Knauer, R.H. Stauber, Nat. Nanotechnol. 8 (10), 772 (2013).

    Google Scholar 

  23. J. Shi, H.L. Karlsson, K. Johansson, V. Gogvadze, L. Xiao, J. Li, T. Burks, A. Garcia-Bennett, A. Uheida, M. Muhammed, S. Mathur, R. Morgenstern, V.E. Kagan, B. Fadeel, ACS Nano 6 (3), 1925 (2012).

    Google Scholar 

  24. W.S. Cho, R. Duffin, F. Thielbeer, M. Bradley, I.L. Megson, W. MacNee, C.A. Poland, C.L. Tran, K. Donaldson, Toxicol. Sci. 126 (2), 469 (2012).

    Google Scholar 

  25. F. Wang, L. Yu, M.P. Monopoli, P. Sandin, E. Mahon, A. Salvati, K.A. Dawson, Nanomedicine 9 (8), 1159 (2013).

    Google Scholar 

  26. F.T. Andón, B. Fadeel, Acc. Chem. Res. 46 (3), 733 (2013).

    Google Scholar 

  27. H.L. Karlsson, M.S. Toprak, B. Fadeel, in Handbook on the Toxicology of Metals, G. Nordberg, B. Fowler, M. Nordberg, Eds. (Elsevier, London, 2014), chap. 4, pp. 75–108.

  28. W.S. Cho, R. Duffin, C.A. Poland, S.E. Howie, W. MacNee, M. Bradley, I.L. Megson, K. Donaldson, Environ. Health Perspect. 118 (12), 1699 (2010).

    Google Scholar 

  29. W.S. Cho, R. Duffin, M. Bradley, I.L. Megson, W. MacNee, J.K. Lee, J. Jeong, K. Donaldson, Part. Fibre Toxicol. 10 (1), 55 (2013).

    Google Scholar 

  30. H. Zhang, Z. Ji, T. Xia, H. Meng, C. Low-Kam, R. Liu, S. Pokhrel, S. Lin, X. Wang, Y.P. Liao, M. Wang, L. Li, R. Rallo, R. Damoiseaux, D. Telesca, L. Mädler, Y. Cohen, J.I. Zink, A.E. Nel, ACS Nano 6 (5), 4349 (2012).

    Google Scholar 

  31. S. Tuomela, R. Autio, T. Buerki-Thurnherr, O. Arslan, A. Kunzmann, B. Andersson-Willman, P. Wick, S. Mathur, A. Scheynius, H.F. Krug, B. Fadeel, R. Lahesmaa, PLoS One 8 (7), e68415 (2013).

  32. L. Kong, S. Tuomela, L. Hahne, H. Ahlfors, O. Yli-Harja, B. Fadeel, R. Lahesmaa, R. Autio, PLoS One 8 (7), e68414 (2013).

  33. J. Liu, Z. Wang, F.D. Liu, A.B. Kane, R.H. Hurt, ACS Nano 6 (11), 9887 (2012).

    Google Scholar 

  34. Z. Wang, A. von dem Bussche, P.K. Kabadi, A.B. Kane, R.H. Hurt, ACS Nano 7 (10), 8715 (2013).

    Google Scholar 

  35. W.J. Stark, Angew. Chem. Int. Ed. Engl. 50 (6), 1242 (2011).

    Google Scholar 

  36. A.R. Gliga, S. Skoglund, I. Odnevall Wallinder, B. Fadeel, H.L. Karlsson, Part. Fibre Toxicol. 11, 11 (2014).

    Google Scholar 

  37. T. Xia, M. Kovochich, M. Liong, L. Mädler, B. Gilbert, H. Shi, J.I. Yeh, J.I. Zink, A.E. Nel, ACS Nano 2 (10), 2121 (2008).

    Google Scholar 

  38. S. George, S. Pokhrel, T. Xia, B. Gilbert, Z. Ji, M. Schowalter, A. Rosenauer, R. Damoiseaux, K.A. Bradley, L. Mädler, A.E. Nel. ACS Nano 4 (1), 15 (2010).

  39. T. Xia, Y. Zhao, T. Sager, S. George, S. Pokhrel, N. Li, D. Schoenfeld, H. Meng, S. Lin, X. Wang, M. Wang, Z. Ji, J.I. Zink, L. Mädler, V. Castranova, S. Lin, A.E. Nel, ACS Nano 5 (2), 1223 (2011).

    Google Scholar 

  40. T. Buerki-Thurnherr, L. Xiao, L. Diener, O. Arslan, C. Hirsch, X. Maeder-Althaus, K. Grieder, B. Wampfler, S. Mathur, P. Wick, H.F. Krug, Nanotoxicology 7 (4), 402 (2013).

    Google Scholar 

  41. R. Li, Z. Ji, C.H. Chang, D.R. Dunphy, X. Cai, H. Meng, H. Zhang, B. Sun, X. Wang, J. Dong, S. Lin, M. Wang, Y.P. Liao, C.J. Brinker, A. Nel, T. Xia, ACS Nano 8 (2), 1771 (2014).

    Google Scholar 

  42. G.P. Kotchey, S.A. Hasan, A.A. Kapralov, S.H. Ha, K. Kim, A.A. Shvedova V.E. Kagan, A. Star, Acc. Chem. Res. 45 (10), 1770 (2012).

    Google Scholar 

  43. F.T. Andon, B. Fadeel, in Nano-Oncologicals: New Targeting and Delivery Approaches, M.J. Alonso, M. Garcia-Fuentes, Eds. (Springer, New York, 2014), chap. 14.

  44. I. Lynch, A. Ahluwalia, D. Boraschi, H.J. Byrne, B. Fadeel, P. Gehr, A.C. Gutleb, M. Kendall, M.G. Papadopoulos, BioNanoMaterials. 14 (3–4), 195 (2013).

  45. R.M. Pearson, H.-J. Hsu, J. Bugno, S. Hong, MRS Bull. 39, 227 (2014).

    Google Scholar 

Download references

Acknowledgements

Supported by the Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning (FORMAS), and the European Commission (FP7-NANOMMUNE, Grant No. 214281; FP7-MARINA, Grant No. 263215; FP7-NANOREG, Grant No. 310584; FP7-SUN, Grant No. 604305; COST Action MODENA, TD1204; Flagship Project GRAPHENE, Grant No. 604391).

Author information

Authors and Affiliations

  1. Nanosafety and Nanomedicine Laboratory, Institute of Environmental Medicine, Karolinska Institutet, Sweden

    Kunal Bhattacharya, Lucian Farcal & Bengt Fadeel

Authors
  1. Kunal Bhattacharya
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Lucian Farcal
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Bengt Fadeel
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Kunal Bhattacharya.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Bhattacharya, K., Farcal, L. & Fadeel, B. Shifting identities of metal oxide nanoparticles: Focus on inflammation. MRS Bulletin 39, 970–975 (2014). https://doi.org/10.1557/mrs.2014.220

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1557/mrs.2014.220

Search

Navigation