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Graphene oxide coated popcorn-like Ag nanoparticles for reliable sensitive surface-enhanced Raman scattering detection of drug residues

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Abstract

Conventional methods for determination of trace drug residues are either time consuming or labor intensive or require large specialized instruments, which hamper their practical applications in field analysis. Here, we present a rapid and quantitative surface-enhanced Raman scattering (SERS) detection method coupled with a portable Raman spectrometer for determination of trace drug residues on fish surface. Graphene oxide (GO) decorated popcorn-like Ag nanoparticles (NPs) on Cu plate (GO/AgNPs/Cu) were fabricated by a facile approach and directly employed as a robust SERS detection substrate. For practical SERS detections, trace-level residues of crystal violet (10−8 M, 4.1 ng/g) and malachite green (10−8 M, 3.6 ng/g) could be readily detected by simply swabbing the contaminated fish scale surface with the SERS substrate. Importantly, SERS detection was quantitatively realized in the broad linear concentrations. Compared with lab-based Raman spectrometer with large footprints, our method has potential applications in practical rapid, accurate, and on-site SERS determination.

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Acknowledgments

We thank the National Natural Science Foundation of China (No. 61205150), Project of Application Breeding Program of Hefei University of Technology (JZ2016YYPY0060), the Youth Academic Team Capacity Promotion Program (PA2017GDQT0023), and the Startup Foundation of Hefei University of Technology (JZ2015HGBZ0127, XC2015JZBZ17) for financial supports.

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Authors and Affiliations

  1. School of Materials Science and Engineering, Hefei University of Technology, Hefei, 230009, People’s Republic of China

    Maofeng Zhang, Zhexue Chen, Zhuoer Wang & Zhiyuan Zheng

  2. Institute of Intelligent Machines, Chinese Academy of Sciences, Hefei, 230031, People’s Republic of China

    Dapeng Wang

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  1. Maofeng Zhang
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  2. Zhexue Chen
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Correspondence to Maofeng Zhang or Dapeng Wang.

Supplementary Material

43578_2019_34172935_MOESM1_ESM.docx

Supporting Information: Graphene oxide coated popcorn-like Ag nanoparticles for reliable sensitive SERS detection of drug residues (approximately 344 KB)

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Zhang, M., Chen, Z., Wang, Z. et al. Graphene oxide coated popcorn-like Ag nanoparticles for reliable sensitive surface-enhanced Raman scattering detection of drug residues. Journal of Materials Research 34, 2935–2943 (2019). https://doi.org/10.1557/jmr.2019.78

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