Abstract
To achieve the goal of biocompatibility in nano-based materials we must first obtain a fundamental understanding of the physical and chemical behavior of biomolecules at the interfaces of nanomaterials. A first step towards understanding protein interactions with nanomaterials is to understand how individual amino acids interact at the interfaces. In this paper, we investigated the lysine adsorption behavior on fumed silica nanoparticles by solid-state NMR spectroscopy. We use 1H, 13C and 15N solid-state magic angle spinning (MAS) NMR techniques to elucidate how lysine is adsorbed on silica nanoparticles surfaces via strong hydrogen-bonding interaction between the protonated side-chain amine group and silanol group on silica nanoparticles surfaces.
Similar content being viewed by others
References
D. Tarn, C. E. Ashley, M. Xue, E. C. Carnes, J. I. Zink and C. J. Brinker, Acc. Chem. Res. 46, 792–801 (2013).
C. E. Ashley, E. C. Carnes, G. K. Phillips, D. Padilla, P. N. Durfee, P. A. Brown, T. N. Hanna, J. Liu, B. Phillips, M. B. Carter, N. J. Carroll, X. Jiang, D. R. Dunphy, C. L. Willman, D. N. Petsev, D. G. Evans, A. N. Parikh, B. Chackerian, W. Wharton, D. S. Peabody and C. J. Brinker, Nat. Mater. 10, 389–397 (2011).
J. A. Hubbell and A. Chilkoti, Science 337, 303–305 (2012).
J. Liu, A. Stace-Naughton, X. Jiang and C. J. Brinker, J. Am. Chem. Soc. 131, 1354–1355 (2009).
S. V. Patwardhan, F. S. Emami, R. J. Berry, S. E. Jones, R. R. Naik, O. Deschaume, H. Heinz and C. C. Perry, J. Am. Chem. Soc. 134, 6244–6256 (2012).
A. A. Shemetov, I. Nabiev and A. Sukhanova, ACS Nano 6, 4585–4602 (2012).
A. Rimola, D. Costa, M. Sodupe, J. F. Lambert and P. Ugliengo, Chem. Rev. 113, 4216–4313 (2013).
L. Zhu, C. Zhang, C. Guo, X. Wang, P. Sun, D. Zhou, W. Chen and G. Xue, J. Phys. Chem. C 117, 11399–11404 (2013).
C. Yu, L. Zhu, R. Zhang, X. Wang, C. Guo, P. Sun and G. Xue, J. Phys. Chem. C 118, 10434–10440 (2014).
H. Qian, M. Zhu, C. Gayathri, R. R. Gil and R. Jin, ACS Nano 5, 8935–8942 (2011).
I. Ben Shir, S. Kababya, T. Amitay-Rosen, Y. S. Balazs and A. Schmidt, J. Phys. Chem. B 114, 5989–5996 (2010).
I. Ben Shir, S. Kababya and A. Schmidt, J. Phys. Chem. C 116, 9691–9702 (2012).
T. Amitay-Rosen and S. Vega, Phys. Chem. Chem. Phys. 12, 6763–6773 (2010).
T. Amitay-Rosen, S. Kababya and S. Vega, J. Phys. Chem. B 113, 6267–6282 (2009).
P. A. Mirau, J. L. Serres and M. Lyons, Chem. Mater. 20, 2218–2223 (2008).
I. Ben Shir, S. Kababya and A. Schmidt, J. Phys. Chem. C 118, 7901–7909 (2014).
C. Guo and G. P. Holland, J. Phys. Chem. C 118, 25792–25801 (2014).
C. Guo and G. P. Holland, J. Phys. Chem. C 119, 25663–25672 (2015).
T. Yokoi, Y. Sakamoto, O. Terasaki, Y. Kubota, T. Okubo and T. Tatsumi, J. Am. Chem. Soc. 128, 13664–13665 (2006).
T. Yokoi, J. Wakabayashi, Y. Otsuka, W. Fan, M. Iwama, R. Watanabe, K. Aramaki, A. Shimojima, T. Tatsumi and T. Okubo, Chem. Mater. 21, 3719–3729 (2009).
M. R. Bendall and R. E. Gordon, J. Magn. Reson. 53, 365–385 (1983).
S. R. Hartmann and E. L. Hahn, Phys. Rev. 128, 2042–2053 (1962).
S. Hayashi and K. Hayamizu, Bull. Chem. Soc. Jpn. 64, 685–687 (1991).
S. Hayashi and K. Hayamizu, Bull. Chem. Soc. Jpn. 64, 688–690 (1991).
Author information
Authors and Affiliations
Additional information
This paper is based on the research presented at MRS Meeting, 2016, Spring
Rights and permissions
About this article
Cite this article
Guo, C., Holland, G.P. & Yarger, J.L. Lysine-Capped Silica Nanoparticles: A Solid-State NMR Spectroscopy Study. MRS Advances 1, 2261–2266 (2016). https://doi.org/10.1557/adv.2016.365
Published:
Issue Date:
DOI: https://doi.org/10.1557/adv.2016.365