Abstract
This paper describes the selective and reproducible debenzylation of benzyloxypyrazinones using flow chemistry to yield N-hydroxypyrazinones. Flow methodology enabled us to avoid overreduction of the compounds to pyrazin-2 (1H)-ones.
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Mai, A.H., De Borggraeve, W.M. Synthesis of N-Hydroxypyrazin-2(1H)-ones via Selective O-Debenzylation of 1-Benzyloxypyrazin-2(1H)-ones Using Flow Methodology. J Flow Chem 5, 6–10 (2015). https://doi.org/10.1556/JFC-D-14-00036
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DOI: https://doi.org/10.1556/JFC-D-14-00036