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Surgery is a Viable Treatment Option for Stage IE Primary Thyroid Lymphoma

  • Endocrine Tumors
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Abstract

Background

Stage IE primary thyroid lymphoma (PTL) has been diagnosed in approximately half of patients with PTL; however, the optimal treatment for stage IE PTL has not yet been established.

Methods

Stage IE PTL patients were identified from the Surveillance, Epidemiology, and End Results (SEER) database between 1998 and 2019. Thereafter, the disease-specific survival (DSS) and treatment modalities (surgery alone, surgery + radiotherapy (RT) and/or chemotherapy (CT), and RT and/or CT) of these patients were compared by Kaplan–Meier curves and log-rank test after propensity score matching (PSM). Additionally, patients with PTL from the Affiliated Sixth People’s Hospital of the Shanghai Jiao Tong University and School of Medicine (Shanghai, China) between 2007 and 2022 were retrospectively analyzed as an external cohort.

Results

Among the 1596 patients with PTL from the SEER database, 842 were identified as patients with stage IE PTL, with an average follow-up period of 7.8 years. Pairwise analysis after PSM revealed no significant difference between the DSS of the three treatment groups. A total of 38 patients with PTL were identified in the external cohort, with an average follow-up period of 3.4 years. Compared with the RT and/or CT group, the surgery-alone group showed no significant difference in the incidence of hypothyroidism (p = 0.161) but had significantly fewer treatment-related complications (p = 0.021), shorter treatment duration (p < 0.001), and lower treatment costs (p = 0.025).

Conclusions

The results of our study demonstrate that surgery is a viable treatment option for patients with stage IE PTL.

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Acknowledgment

The authors would like to thank LetPub (www.letpub.com) for their linguistic assistance during the preparation of this manuscript.

Funding

Research reported in this publication was supported in part by the Natural Science Foundation of Shanghai (21ZR1448500) and Hospital-Level Clinical Research Fund of Shanghai Sixth People’s Hospital (YNLC201905).

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Author notes

  1. Yufan Tang and Ting Yan contributed equally to this work and should be regarded as co-first authors.

Authors and Affiliations

  1. Department of Thyroid, Parathyroid, Breast and Hernia Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

    Yufan Tang MB, Ting Yan MS, Wangwang Qiu MS, Zheng Ding MD, Youben Fan MD & Zhili Yang MD

  2. Department of Pathology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

    Qiong Jiao MD

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  1. Yufan Tang MB
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  2. Ting Yan MS
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  7. Zhili Yang MD
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Contributions

Formal analysis, visualization, writing—original draft: YT. Conceptualization, methodology, writing—review and editing: TY. Data curation: WQ. Investigation: ZD. Validation: YF. Supervision: QJ. Project administration: ZY.

Corresponding authors

Correspondence to Qiong Jiao MD or Zhili Yang MD.

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Disclosure

Yufan Tang, Ting Yan, Wangwang Qiu, Zheng Ding, Youben Fan, Qiong Jiao, and Zhili Yang have no commercial or financial interests to declare.

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Tang, Y., Yan, T., Qiu, W. et al. Surgery is a Viable Treatment Option for Stage IE Primary Thyroid Lymphoma. Ann Surg Oncol 31, 1108–1115 (2024). https://doi.org/10.1245/s10434-023-14535-8

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  • DOI: https://doi.org/10.1245/s10434-023-14535-8

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