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Hepatopancreatoduodenectomy for Multifocal Cholangiocarcinoma in the Setting of Biliary Papillomatosis

  • Hepatobiliary Tumors
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

Hepatopancreatoduodenectomy is performed to achieve curative resection of malignant biliary tumors.1 However, the morbidity and mortality associated with this challenging surgical procedure remain high, and optimal indications remain unclear.2,3,–4 Biliary papillomatosis (BP) is a precursor lesion of cholangiocarcinoma. This video shows hepatopancreatoduodenecomy for multifocal cholangiocarcinoma in the setting of BP.

Patient

A 75-year-old man with a medical history of cholecystectomy presented with obstructive jaundice. Magnetic resonance colangiopancreatography and computed tomography scan showed diffuse biliary dilation with mild enhancing nodularities in the whole extrahepatic bile duct. Cholangioscopy with biopsies proved cholangiocarcinoma arising from BP at the prepapillary common bile duct (CBD) and the biliary confluence. The second-order right ducts were free of disease. The patient underwent nasobiliary drainage and was considered for hepatopancreatoduodenecomy.

Technique

A right subcostal incision was performed. Intraoperative ultrasound showed BP of the intrapancreatic CBD spreading only to the left bile duct. En bloc resection of the left liver, caudate lobe, and CBD was performed together with pylorus-preserving pancreatoduodenectomy. The reconstruction phase was performed on a single-loop by duct-to-mucosa pancreatojejunostomy, two-duct biliojejunostomy with mucosa-to-mucosa alignment, and duodenojejunostomy. Transanastomotic external stents were used for biliary and pancreatic drainage. Histopathologic examination confirmed foci of cholangiocarcinoma arising from BP. Resection margins were negative. Lymph node metastasis, microvascular invasion, perineural invasion, and mucin secretion were absent. The patient was discharged on postoperative day 14 without complications. At the 2-year follow-up assessment, he was alive and free of disease.

Conclusion

Cholangiocarcinoma arising from BP is a proper indication for hepatopancreatoduodenectomy. The long-term oncologic benefits might outweigh the possible perioperative complications.5,6

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Authors and Affiliations

  1. Division of General and HPB Surgery, Department of Surgery, School of Medicine, University of Verona, Verona, Italy

    Calogero Iacono MD, Mario De Bellis MD, Andrea Ruzzenente MD, PhD, Tommaso Campagnaro MD, Simone Conci MD, PhD & Alfredo Guglielmi MD

Authors
  1. Calogero Iacono MD
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  2. Mario De Bellis MD
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  3. Andrea Ruzzenente MD, PhD
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  4. Tommaso Campagnaro MD
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  5. Simone Conci MD, PhD
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  6. Alfredo Guglielmi MD
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Correspondence to Calogero Iacono MD.

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Iacono, C., De Bellis, M., Ruzzenente, A. et al. Hepatopancreatoduodenectomy for Multifocal Cholangiocarcinoma in the Setting of Biliary Papillomatosis. Ann Surg Oncol 27, 3356–3357 (2020). https://doi.org/10.1245/s10434-020-08357-1

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  • DOI: https://doi.org/10.1245/s10434-020-08357-1

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