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The Differential Impact of Body Mass Index and the Feature of Metabolic Syndrome on Oncological Outcomes Following Different Surgical Procedures in Japanese Men with Prostate Cancer

  • Urologic Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Purpose

This study aimed to examine the differential impact of body mass index and the feature of metabolic syndrome (MetS; obesity, hypertension, diabetes mellitus, and dyslipidemia) on biochemical recurrence (BCR) following radical prostatectomy (RP) treatment for prostate cancer using different surgical procedures.

Methods

This study included 283 Japanese patients with clinically localized prostate cancer who were treated with RP between 2008 and 2012. The prognostic significance of overweight and the feature of MetS were analyzed according to surgical procedures.

Results

BCR occurred in 68/283 (24.0%) men. Overweight and the feature of MetS were predictors of BCR in patients who had undergone open RP (ORP), but not in those treated with laparoscopic surgery. Multivariate analyses incorporating preoperative and postoperative risk factors revealed that overweight and the feature of MetS were independent BCR risk factors when treated with ORP.

Conclusions

In Japanese men, overweight and the feature of MetS were associated with worse outcomes following RP, particularly ORP, compared with those following laparoscopic surgery. These results suggest that laparoscopic surgery can overcome the surgical challenges associated with abdominal obesity.

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Acknowledgement

The authors would like to thank the Edanz Group Japan for editorial assistance.

Funding

This work was supported by a Research Promotion Grant from the Daiwa Securities Health Foundation, Japan, and a Research Promotion Grant from the Smoking Research Foundation, Japan.

Disclosure

Masaki Shiota, Ario Takeuchi, Masaaki Sugimoto, Eiji Kashiwagi, Takashi Dejima, Keijiro Kiyoshima, Junichi Inokuchi, Katsunori Tatsugami, Akira Yokomizo, and Masatoshi Eto declare no conflicts of interest.

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Authors and Affiliations

  1. Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Masaki Shiota MD, PhD, Ario Takeuchi MD, PhD, Masaaki Sugimoto MD, PhD, Eiji Kashiwagi MD, PhD, Takashi Dejima MD, PhD, Keijiro Kiyoshima MD, PhD, Junichi Inokuchi MD, PhD, Katsunori Tatsugami MD, PhD, Akira Yokomizo MD, PhD & Masatoshi Eto MD, PhD

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  1. Masaki Shiota MD, PhD
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  2. Ario Takeuchi MD, PhD
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  3. Masaaki Sugimoto MD, PhD
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  5. Takashi Dejima MD, PhD
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  7. Junichi Inokuchi MD, PhD
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  8. Katsunori Tatsugami MD, PhD
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  9. Akira Yokomizo MD, PhD
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  10. Masatoshi Eto MD, PhD
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Correspondence to Masaki Shiota MD, PhD.

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Shiota, M., Takeuchi, A., Sugimoto, M. et al. The Differential Impact of Body Mass Index and the Feature of Metabolic Syndrome on Oncological Outcomes Following Different Surgical Procedures in Japanese Men with Prostate Cancer. Ann Surg Oncol 24, 1443–1450 (2017). https://doi.org/10.1245/s10434-016-5705-2

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  • DOI: https://doi.org/10.1245/s10434-016-5705-2

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