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Breast Cancer in Male Adolescents and Young Adults

  • Breast Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

Breast cancer is one of the most common cancers in female adolescent and young adults (AYA; age 15–39 years). However, few data exist detailing either in situ or invasive breast cancer in male AYAs.

Methods

All male AYA breast cancer cases were identified in the National Cancer Data Base (1998–2010). Demographics, tumor, and treatment predictors of overall survival (OS) were determined for both patients with in situ and invasive tumors.

Results

Of 677 male AYAs, 122 patients (18 %) had in situ breast cancer, while 555 patients (82 %) were found to have invasive breast cancer. Compared to in situ breast cancer, invasive breast cancer in male AYAs was less likely to occur in patients with private or managed care insurance (p = 0.003) or <20 years of age (p = 0.028). In patients with invasive breast cancer, lower OS was associated with age ≤25 years (p = 0.006), black race (p = 0.018), not having Medicaid/Medicare/government/military insurance (p < 0.001), the lowest socioeconomic status (p = 0.001), higher overall stage (p < 0.001), T stage (p < 0.001), nodal stage (p < 0.001), and M stage (p < 0.001), as well as not having any surgery (p < 0.001) or nodal evaluation at surgery (p < 0.001). After controlling for competing factors, only age ≤25 years (hazard ratio 3.064, 95 % confidence interval 1.216–7.720) and not having nodal evaluation (hazard ratio 3.070, 95 % confidence interval 1.423–6.626) predicted decreased OS.

Conclusions

Younger age and not having nodal evaluation at the time of surgery are associated with decreased OS in AYA male patients with invasive cancer. This highlights the need to perform axillary node sampling through sentinel node biopsy at the time of mastectomy in these young male patients.

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Acknowledgment

The data used in this study was derived from a deidentified NCDB file. The American College of Surgeons and the Commission on Cancer have not verified and are not responsible for the analytic or statistical methodology used, or any conclusions drawn from this data by the investigators.

Disclosure

The authors declare no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Surgical Oncology, John Wayne Cancer Institute at Providence Saint John’s Health Center, Santa Monica, CA, USA

    Devin C. Flaherty DO, PhD, Rashmi Bawa MD & Melanie Goldfarb MD, MSc, FACS, FACE

  2. Department of Urology, University of California Los Angeles, Los Angeles, CA, USA

    Claire Burton MD

Authors
  1. Devin C. Flaherty DO, PhD
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  2. Rashmi Bawa MD
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  3. Claire Burton MD
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  4. Melanie Goldfarb MD, MSc, FACS, FACE
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Corresponding author

Correspondence to Melanie Goldfarb MD, MSc, FACS, FACE.

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Flaherty, D.C., Bawa, R., Burton, C. et al. Breast Cancer in Male Adolescents and Young Adults. Ann Surg Oncol 24, 84–90 (2017). https://doi.org/10.1245/s10434-016-5586-4

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  • DOI: https://doi.org/10.1245/s10434-016-5586-4

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