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Postoperative Serum Albumin Level is a Marker of Incomplete Adjuvant Chemotherapy in Patients with Pancreatic Ductal Adenocarcinoma

  • Pancreatic Tumors
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

Adjuvant chemotherapy (AC) is recommended as a standard treatment after curative resection in patients with pancreatic adenocarcinoma (PA). Although patients who failed to complete AC had significantly worse survival compared with those who completed AC for cancers in various organs, the effects of complete AC on survival in patients with PA have not been investigated. The purpose of this study was to clarify the impact of complete AC on PA patient survival and to identify independent risk factors for incomplete AC.

Methods

Medical records of 236 consecutive PA patients who planned to undergo surgical resection with curative intent between January 2000 and September 2012 at Kobe University Hospital were retrospectively reviewed. Of these, the complete AC (n = 75) and the incomplete AC (n = 30) groups due to adverse events were compared.

Results

Patient survival was significantly better in the complete AC group than in the incomplete AC group (median survival time 48.9 vs. 17.9 months; 5-year survival rate 42.7 vs. 17.1 %; p < 0.0001). Preoperative white blood cell count and postoperative serum albumin level were identified as independent risk factors for incomplete AC. By receiver operating characteristic curve analysis, the cutoff value of postoperative serum albumin level was 3.1 mg/dL.

Conclusions

PA patients who completed AC had significantly better survival than those who failed to complete AC. Postoperative serum albumin level is a marker for failure to complete AC. Further prospective studies are needed to determine whether perioperative nutritional intervention could increase AC completion rate and improve prognosis in PA patients.

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Disclosure

The authors have no conflicts of interest to disclose.

Funding

No grant support was provided for this study.

Author information

Authors and Affiliations

  1. Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan

    Ippei Matsumoto MD, PhD, Masaki Tanaka MD, PhD, Sachiyo Shirakawa MD, PhD, Makoto Shinzeki MD, PhD, Hirochika Toyama MD, PhD, Sadaki Asari MD, PhD, Tadahiro Goto MD, PhD, Hironori Yamashita MD, PhD, Jun Ishida MD, Tetsuo Ajiki MD, PhD, Takumi Fukumoto MD, PhD & Yonson Ku MD, PhD

  2. Department of Surgery, Kinki University Faculty of Medicine, Osakasayama, Osaka, Japan

    Ippei Matsumoto MD, PhD

  3. Cancer Biostatistics Laboratory, Clinical Research Institute, National Kyushu Cancer Center, Fukuoka, Japan

    Mototsugu Shimokawa PhD

Authors
  1. Ippei Matsumoto MD, PhD
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  2. Masaki Tanaka MD, PhD
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  3. Sachiyo Shirakawa MD, PhD
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  4. Makoto Shinzeki MD, PhD
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  5. Hirochika Toyama MD, PhD
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  6. Sadaki Asari MD, PhD
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  7. Tadahiro Goto MD, PhD
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  8. Hironori Yamashita MD, PhD
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  9. Jun Ishida MD
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  10. Tetsuo Ajiki MD, PhD
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  11. Takumi Fukumoto MD, PhD
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  12. Mototsugu Shimokawa PhD
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  13. Yonson Ku MD, PhD
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Corresponding author

Correspondence to Ippei Matsumoto MD, PhD.

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Matsumoto, I., Tanaka, M., Shirakawa, S. et al. Postoperative Serum Albumin Level is a Marker of Incomplete Adjuvant Chemotherapy in Patients with Pancreatic Ductal Adenocarcinoma. Ann Surg Oncol 22, 2408–2415 (2015). https://doi.org/10.1245/s10434-014-4280-7

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  • DOI: https://doi.org/10.1245/s10434-014-4280-7

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