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Shorter Dinner-to-Bed Time is Associated with Gastric Cardia Adenocarcinoma Risk Partly in a Reflux-Dependent Manner

  • Gastrointestinal Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

Gastric cancer remains the second cause of cancer-related death worldwide. The aim of this study was to investigate the effects of shorter dinner-to-bed time, post-dinner walk, and obesity on gastric cardia adenocarcinoma (GCA) risk.

Methods

The study subjects consisted of 146 GCA patients and 166 healthy controls roughly matched by gender and age. Conditional logistic regression was used to calculated odds ratio (OR) and 95 % confidence intervals (CIs).

Results

The adjusted ORs of GCA for subjects with shorter dinner-to-bed time were 4.18 (95 % CI 2.10–8.33) compared with those with longer dinner-to-bed time. What is more, when reflux symptom was added into the multivariate models, risk estimate for shorter dinner-to-bed time decreased greatly, but still remained statistically significant (p = 0.007). Post-dinner walk was associated with a significantly decreased GCA risk (adjusted OR 0.54; 95 % CI 0.31–0.94). When subjects were analyzed according to post-dinner walk, the adjusted OR of GCA for shorter dinner-to-bed time relative to longer dinner-to-bed time was much higher for non-walking subjects (adjusted OR 20.21) than walking subjects (adjusted OR 1.39). We further found a significant interaction between shorter dinner-to-bed time and post-dinner walk regarding the risk of GCA (adjusted OR 0.07; p = 0.001).

Conclusions

We found that shorter dinner-to-bed time was associated with significantly increased GCA risk, partly depending on reflux symptoms, while post-dinner walk was related to a significantly decreased GCA risk and could greatly attenuate the GCA risk attributable to shorter dinner-to-bed time.

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Acknowledgment

The authors thank Dr. Tian H (Department of Thoracic Surgery, Qilu Hospital of Shandong University) for subject recruitment. This work was supported by the China Postdoctoral Science Fund (number 2011M500531) and Science and Technology Plan Project of Shandong Province (Grant number 2012 GSF11852).

Conflict of interest

The authors declare no conflicts of interest.

Author information

Authors and Affiliations

  1. Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, People’s Republic of China

    Qingxu Song MM, Jianbo Wang MD, Yibin Jia MD, Nana Wang MD, Bingxu Tan MD, Wei Ma MD, Shanghui Guan MD, Dong Jiang MM & Yufeng Cheng MD, PhD

  2. Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, People’s Republic of China

    Chuan Wang MD

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  1. Qingxu Song MM
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  2. Jianbo Wang MD
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Correspondence to Yufeng Cheng MD, PhD.

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Song, Q., Wang, J., Jia, Y. et al. Shorter Dinner-to-Bed Time is Associated with Gastric Cardia Adenocarcinoma Risk Partly in a Reflux-Dependent Manner. Ann Surg Oncol 21, 2615–2619 (2014). https://doi.org/10.1245/s10434-014-3628-3

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  • DOI: https://doi.org/10.1245/s10434-014-3628-3

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